Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Y5D

Structure of human cGAS (K394E) bound to the nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0046982	molecular_function	protein heterodimerization activity
C	0070062	cellular_component	extracellular exosome
D	0000786	cellular_component	nucleosome
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0046982	molecular_function	protein heterodimerization activity
G	0070062	cellular_component	extracellular exosome
H	0000786	cellular_component	nucleosome
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0046982	molecular_function	protein heterodimerization activity
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0030527	molecular_function	structural constituent of chromatin
M	0046982	molecular_function	protein heterodimerization activity
N	0000781	cellular_component	chromosome, telomeric region
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006334	biological_process	nucleosome assembly
N	0016020	cellular_component	membrane
N	0030527	molecular_function	structural constituent of chromatin
N	0032200	biological_process	telomere organization
N	0032991	cellular_component	protein-containing complex
N	0043505	cellular_component	CENP-A containing nucleosome
N	0045653	biological_process	negative regulation of megakaryocyte differentiation
N	0046982	molecular_function	protein heterodimerization activity
N	0061644	biological_process	protein localization to CENP-A containing chromatin
N	0070062	cellular_component	extracellular exosome
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0030527	molecular_function	structural constituent of chromatin
O	0031507	biological_process	heterochromatin formation
O	0046982	molecular_function	protein heterodimerization activity
O	0070062	cellular_component	extracellular exosome
P	0000786	cellular_component	nucleosome
P	0002227	biological_process	innate immune response in mucosa
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005829	cellular_component	cytosol
P	0019731	biological_process	antibacterial humoral response
P	0030527	molecular_function	structural constituent of chromatin
P	0031640	biological_process	killing of cells of another organism
P	0042742	biological_process	defense response to bacterium
P	0046982	molecular_function	protein heterodimerization activity
P	0050829	biological_process	defense response to Gram-negative bacterium
P	0050830	biological_process	defense response to Gram-positive bacterium
P	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity
R	0000781	cellular_component	chromosome, telomeric region
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0006325	biological_process	chromatin organization
R	0006334	biological_process	nucleosome assembly
R	0016020	cellular_component	membrane
R	0030527	molecular_function	structural constituent of chromatin
R	0032200	biological_process	telomere organization
R	0032991	cellular_component	protein-containing complex
R	0043505	cellular_component	CENP-A containing nucleosome
R	0045653	biological_process	negative regulation of megakaryocyte differentiation
R	0046982	molecular_function	protein heterodimerization activity
R	0061644	biological_process	protein localization to CENP-A containing chromatin
R	0070062	cellular_component	extracellular exosome
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0031507	biological_process	heterochromatin formation
S	0046982	molecular_function	protein heterodimerization activity
S	0070062	cellular_component	extracellular exosome
T	0000786	cellular_component	nucleosome
T	0002227	biological_process	innate immune response in mucosa
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005615	cellular_component	extracellular space
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005694	cellular_component	chromosome
T	0005829	cellular_component	cytosol
T	0019731	biological_process	antibacterial humoral response
T	0030527	molecular_function	structural constituent of chromatin
T	0031640	biological_process	killing of cells of another organism
T	0042742	biological_process	defense response to bacterium
T	0046982	molecular_function	protein heterodimerization activity
T	0050829	biological_process	defense response to Gram-negative bacterium
T	0050830	biological_process	defense response to Gram-positive bacterium
T	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PTD A 201

Chain	Residue
A	LYS80
B	LYS80

site_id	AC2
Number of Residues	2
Details	binding site for residue PTD C 201

Chain	Residue
C	LYS100
G	LYS100

site_id	AC3
Number of Residues	1
Details	binding site for residue ZN K 601

Chain	Residue
K	CYS396

site_id	AC4
Number of Residues	1
Details	binding site for residue ZN L 601

Chain	Residue
L	CYS396

site_id	AC5
Number of Residues	7
Details	binding site for Di-peptide PTD G 701 and LYS K 355

Chain	Residue
K	LEU352
K	ARG353
K	LEU354
K	PRO356
G	ARG72
G	LYS75
K	TRP330

site_id	AC6
Number of Residues	5
Details	binding site for Di-peptide PTD H 301 and LYS H 35

Chain	Residue
D	LYS86
H	ARG34
H	GLU36
I	DC126
I	DA127

site_id	AC7
Number of Residues	6
Details	binding site for Di-peptide PTD H 302 and LYS H 86

Chain	Residue
C	LYS37
H	ALA82
H	HIS83
H	TYR84
H	ASN85
H	ARG87

site_id	AC8
Number of Residues	5
Details	binding site for Di-peptide PTD M 201 and LYS M 80

Chain	Residue
M	ALA76
M	GLN77
M	PHE79
M	THR81
N	LYS80

site_id	AC9
Number of Residues	9
Details	binding site for Di-peptide PTD M 201 and LYS N 80

Chain	Residue
M	ALA76
M	GLN77
M	PHE79
M	THR81
M	ASP82
M	LEU83
M	ARG84
N	ARG79
N	THR81

site_id	AD1
Number of Residues	5
Details	binding site for Di-peptide PTD O 201 and LYS O 100

Chain	Residue
O	LEU98
O	GLY99
O	VAL101
O	THR102
S	LYS100

site_id	AD2
Number of Residues	9
Details	binding site for Di-peptide PTD O 201 and LYS S 100

Chain	Residue
N	GLY95
O	LEU98
O	GLY99
O	VAL101
O	THR102
S	LEU98
S	GLY99
S	VAL101
S	THR102

site_id	AD3
Number of Residues	6
Details	binding site for Di-peptide PTD S 701 and LYS S 75

Chain	Residue
L	LYS355
S	ALA71
S	ARG72
S	ASP73
S	ASN74
S	LYS76

site_id	AD4
Number of Residues	5
Details	binding site for Di-peptide PTD S 701 and LYS L 355

Chain	Residue
L	LEU352
L	ARG353
L	LEU354
L	PRO356
S	LYS75

site_id	AD5
Number of Residues	8
Details	binding site for Di-peptide PTD S 702 and LYS S 37

Chain	Residue
P	LYS86
S	ARG33
S	LEU34
S	LEU35
S	ARG36
S	GLY38
S	ASN39
S	TYR40

site_id	AD6
Number of Residues	14
Details	binding site for Di-peptide PTD S 702 and LYS P 86

Chain	Residue
P	ALA82
P	HIS83
P	TYR84
P	ASN85
P	ARG87
S	LYS37
S	ARG82
S	HIS83
S	LEU84
S	GLN85
S	ALA87
S	ILE88
S	ARG89
S	ASN90

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA22-VAL28

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY15-HIS19

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG93-GLY115

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO67-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	31
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	9
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21076176","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"12086618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17967882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	8
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	4
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q8CGP1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	8
Details	Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	8
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	4
Details	Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	8
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	84
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	82
Details	Region: {"description":"Interaction with collided ribosomes","evidences":[{"source":"PubMed","id":"34111399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	46
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	10
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"33406424","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	20
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	6
Details	Motif: {"description":"KRKR-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	4
Details	Motif: {"description":"KKH-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23722159","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26229115","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32459092","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LRC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	4
Details	Site: {"description":"Important for preferential detection of curved long DNA","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	2
Details	Site: {"description":"Arginine-anchor","evidences":[{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33051594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	2
Details	Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"30878284","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl aspartic acid","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	4
Details	Modified residue: {"description":"(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"33273464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by BLK","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK1 and PKB","evidences":[{"source":"PubMed","id":"26440888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32351706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33542149","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl glutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32474700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	4
Details	Modified residue: {"description":"(Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"35210392","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI71
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"37802025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI72
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"35438208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI74
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI75
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI76
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI77
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI78
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI79
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI80
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"35503863","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI81
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27666593","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI82
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38418882","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)