6Y5D
Structure of human cGAS (K394E) bound to the nucleosome
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000786 | cellular_component | nucleosome |
A | 0003677 | molecular_function | DNA binding |
A | 0030527 | molecular_function | structural constituent of chromatin |
A | 0046982 | molecular_function | protein heterodimerization activity |
B | 0000781 | cellular_component | chromosome, telomeric region |
B | 0000786 | cellular_component | nucleosome |
B | 0003677 | molecular_function | DNA binding |
B | 0003723 | molecular_function | RNA binding |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005694 | cellular_component | chromosome |
B | 0006325 | biological_process | chromatin organization |
B | 0006334 | biological_process | nucleosome assembly |
B | 0016020 | cellular_component | membrane |
B | 0030527 | molecular_function | structural constituent of chromatin |
B | 0032200 | biological_process | telomere organization |
B | 0032991 | cellular_component | protein-containing complex |
B | 0043505 | cellular_component | CENP-A containing nucleosome |
B | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
B | 0046982 | molecular_function | protein heterodimerization activity |
B | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
B | 0070062 | cellular_component | extracellular exosome |
C | 0000786 | cellular_component | nucleosome |
C | 0003674 | molecular_function | molecular_function |
C | 0003677 | molecular_function | DNA binding |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005694 | cellular_component | chromosome |
C | 0008150 | biological_process | biological_process |
C | 0030527 | molecular_function | structural constituent of chromatin |
C | 0031492 | molecular_function | nucleosomal DNA binding |
C | 0031507 | biological_process | heterochromatin formation |
C | 0046982 | molecular_function | protein heterodimerization activity |
C | 0070062 | cellular_component | extracellular exosome |
D | 0000786 | cellular_component | nucleosome |
D | 0002227 | biological_process | innate immune response in mucosa |
D | 0003674 | molecular_function | molecular_function |
D | 0003677 | molecular_function | DNA binding |
D | 0005515 | molecular_function | protein binding |
D | 0005615 | cellular_component | extracellular space |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005694 | cellular_component | chromosome |
D | 0005829 | cellular_component | cytosol |
D | 0019731 | biological_process | antibacterial humoral response |
D | 0030527 | molecular_function | structural constituent of chromatin |
D | 0031640 | biological_process | killing of cells of another organism |
D | 0042742 | biological_process | defense response to bacterium |
D | 0046982 | molecular_function | protein heterodimerization activity |
D | 0050829 | biological_process | defense response to Gram-negative bacterium |
D | 0050830 | biological_process | defense response to Gram-positive bacterium |
D | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
E | 0000786 | cellular_component | nucleosome |
E | 0003677 | molecular_function | DNA binding |
E | 0030527 | molecular_function | structural constituent of chromatin |
E | 0046982 | molecular_function | protein heterodimerization activity |
F | 0000781 | cellular_component | chromosome, telomeric region |
F | 0000786 | cellular_component | nucleosome |
F | 0003677 | molecular_function | DNA binding |
F | 0003723 | molecular_function | RNA binding |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005634 | cellular_component | nucleus |
F | 0005654 | cellular_component | nucleoplasm |
F | 0005694 | cellular_component | chromosome |
F | 0006325 | biological_process | chromatin organization |
F | 0006334 | biological_process | nucleosome assembly |
F | 0016020 | cellular_component | membrane |
F | 0030527 | molecular_function | structural constituent of chromatin |
F | 0032200 | biological_process | telomere organization |
F | 0032991 | cellular_component | protein-containing complex |
F | 0043505 | cellular_component | CENP-A containing nucleosome |
F | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
F | 0046982 | molecular_function | protein heterodimerization activity |
F | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
F | 0070062 | cellular_component | extracellular exosome |
G | 0000786 | cellular_component | nucleosome |
G | 0003674 | molecular_function | molecular_function |
G | 0003677 | molecular_function | DNA binding |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005694 | cellular_component | chromosome |
G | 0008150 | biological_process | biological_process |
G | 0030527 | molecular_function | structural constituent of chromatin |
G | 0031492 | molecular_function | nucleosomal DNA binding |
G | 0031507 | biological_process | heterochromatin formation |
G | 0046982 | molecular_function | protein heterodimerization activity |
G | 0070062 | cellular_component | extracellular exosome |
H | 0000786 | cellular_component | nucleosome |
H | 0002227 | biological_process | innate immune response in mucosa |
H | 0003674 | molecular_function | molecular_function |
H | 0003677 | molecular_function | DNA binding |
H | 0005515 | molecular_function | protein binding |
H | 0005615 | cellular_component | extracellular space |
H | 0005634 | cellular_component | nucleus |
H | 0005654 | cellular_component | nucleoplasm |
H | 0005694 | cellular_component | chromosome |
H | 0005829 | cellular_component | cytosol |
H | 0019731 | biological_process | antibacterial humoral response |
H | 0030527 | molecular_function | structural constituent of chromatin |
H | 0031640 | biological_process | killing of cells of another organism |
H | 0042742 | biological_process | defense response to bacterium |
H | 0046982 | molecular_function | protein heterodimerization activity |
H | 0050829 | biological_process | defense response to Gram-negative bacterium |
H | 0050830 | biological_process | defense response to Gram-positive bacterium |
H | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
M | 0000786 | cellular_component | nucleosome |
M | 0003677 | molecular_function | DNA binding |
M | 0030527 | molecular_function | structural constituent of chromatin |
M | 0046982 | molecular_function | protein heterodimerization activity |
N | 0000781 | cellular_component | chromosome, telomeric region |
N | 0000786 | cellular_component | nucleosome |
N | 0003677 | molecular_function | DNA binding |
N | 0003723 | molecular_function | RNA binding |
N | 0005515 | molecular_function | protein binding |
N | 0005576 | cellular_component | extracellular region |
N | 0005634 | cellular_component | nucleus |
N | 0005654 | cellular_component | nucleoplasm |
N | 0005694 | cellular_component | chromosome |
N | 0006325 | biological_process | chromatin organization |
N | 0006334 | biological_process | nucleosome assembly |
N | 0016020 | cellular_component | membrane |
N | 0030527 | molecular_function | structural constituent of chromatin |
N | 0032200 | biological_process | telomere organization |
N | 0032991 | cellular_component | protein-containing complex |
N | 0043505 | cellular_component | CENP-A containing nucleosome |
N | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
N | 0046982 | molecular_function | protein heterodimerization activity |
N | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
N | 0070062 | cellular_component | extracellular exosome |
O | 0000786 | cellular_component | nucleosome |
O | 0003674 | molecular_function | molecular_function |
O | 0003677 | molecular_function | DNA binding |
O | 0005515 | molecular_function | protein binding |
O | 0005634 | cellular_component | nucleus |
O | 0005694 | cellular_component | chromosome |
O | 0008150 | biological_process | biological_process |
O | 0030527 | molecular_function | structural constituent of chromatin |
O | 0031492 | molecular_function | nucleosomal DNA binding |
O | 0031507 | biological_process | heterochromatin formation |
O | 0046982 | molecular_function | protein heterodimerization activity |
O | 0070062 | cellular_component | extracellular exosome |
P | 0000786 | cellular_component | nucleosome |
P | 0002227 | biological_process | innate immune response in mucosa |
P | 0003674 | molecular_function | molecular_function |
P | 0003677 | molecular_function | DNA binding |
P | 0005515 | molecular_function | protein binding |
P | 0005615 | cellular_component | extracellular space |
P | 0005634 | cellular_component | nucleus |
P | 0005654 | cellular_component | nucleoplasm |
P | 0005694 | cellular_component | chromosome |
P | 0005829 | cellular_component | cytosol |
P | 0019731 | biological_process | antibacterial humoral response |
P | 0030527 | molecular_function | structural constituent of chromatin |
P | 0031640 | biological_process | killing of cells of another organism |
P | 0042742 | biological_process | defense response to bacterium |
P | 0046982 | molecular_function | protein heterodimerization activity |
P | 0050829 | biological_process | defense response to Gram-negative bacterium |
P | 0050830 | biological_process | defense response to Gram-positive bacterium |
P | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Q | 0000786 | cellular_component | nucleosome |
Q | 0003677 | molecular_function | DNA binding |
Q | 0030527 | molecular_function | structural constituent of chromatin |
Q | 0046982 | molecular_function | protein heterodimerization activity |
R | 0000781 | cellular_component | chromosome, telomeric region |
R | 0000786 | cellular_component | nucleosome |
R | 0003677 | molecular_function | DNA binding |
R | 0003723 | molecular_function | RNA binding |
R | 0005515 | molecular_function | protein binding |
R | 0005576 | cellular_component | extracellular region |
R | 0005634 | cellular_component | nucleus |
R | 0005654 | cellular_component | nucleoplasm |
R | 0005694 | cellular_component | chromosome |
R | 0006325 | biological_process | chromatin organization |
R | 0006334 | biological_process | nucleosome assembly |
R | 0016020 | cellular_component | membrane |
R | 0030527 | molecular_function | structural constituent of chromatin |
R | 0032200 | biological_process | telomere organization |
R | 0032991 | cellular_component | protein-containing complex |
R | 0043505 | cellular_component | CENP-A containing nucleosome |
R | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
R | 0046982 | molecular_function | protein heterodimerization activity |
R | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
R | 0070062 | cellular_component | extracellular exosome |
S | 0000786 | cellular_component | nucleosome |
S | 0003674 | molecular_function | molecular_function |
S | 0003677 | molecular_function | DNA binding |
S | 0005515 | molecular_function | protein binding |
S | 0005634 | cellular_component | nucleus |
S | 0005694 | cellular_component | chromosome |
S | 0008150 | biological_process | biological_process |
S | 0030527 | molecular_function | structural constituent of chromatin |
S | 0031492 | molecular_function | nucleosomal DNA binding |
S | 0031507 | biological_process | heterochromatin formation |
S | 0046982 | molecular_function | protein heterodimerization activity |
S | 0070062 | cellular_component | extracellular exosome |
T | 0000786 | cellular_component | nucleosome |
T | 0002227 | biological_process | innate immune response in mucosa |
T | 0003674 | molecular_function | molecular_function |
T | 0003677 | molecular_function | DNA binding |
T | 0005515 | molecular_function | protein binding |
T | 0005615 | cellular_component | extracellular space |
T | 0005634 | cellular_component | nucleus |
T | 0005654 | cellular_component | nucleoplasm |
T | 0005694 | cellular_component | chromosome |
T | 0005829 | cellular_component | cytosol |
T | 0019731 | biological_process | antibacterial humoral response |
T | 0030527 | molecular_function | structural constituent of chromatin |
T | 0031640 | biological_process | killing of cells of another organism |
T | 0042742 | biological_process | defense response to bacterium |
T | 0046982 | molecular_function | protein heterodimerization activity |
T | 0050829 | biological_process | defense response to Gram-negative bacterium |
T | 0050830 | biological_process | defense response to Gram-positive bacterium |
T | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue PTD A 201 |
Chain | Residue |
A | LYS80 |
B | LYS80 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue PTD C 201 |
Chain | Residue |
C | LYS100 |
G | LYS100 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue ZN K 601 |
Chain | Residue |
K | CYS396 |
site_id | AC4 |
Number of Residues | 1 |
Details | binding site for residue ZN L 601 |
Chain | Residue |
L | CYS396 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for Di-peptide PTD G 701 and LYS K 355 |
Chain | Residue |
K | LEU352 |
K | ARG353 |
K | LEU354 |
K | PRO356 |
G | ARG72 |
G | LYS75 |
K | TRP330 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for Di-peptide PTD H 301 and LYS H 35 |
Chain | Residue |
D | LYS86 |
H | ARG34 |
H | GLU36 |
I | DC126 |
I | DA127 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for Di-peptide PTD H 302 and LYS H 86 |
Chain | Residue |
C | LYS37 |
H | ALA82 |
H | HIS83 |
H | TYR84 |
H | ASN85 |
H | ARG87 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for Di-peptide PTD M 201 and LYS M 80 |
Chain | Residue |
M | ALA76 |
M | GLN77 |
M | PHE79 |
M | THR81 |
N | LYS80 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for Di-peptide PTD M 201 and LYS N 80 |
Chain | Residue |
M | ALA76 |
M | GLN77 |
M | PHE79 |
M | THR81 |
M | ASP82 |
M | LEU83 |
M | ARG84 |
N | ARG79 |
N | THR81 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for Di-peptide PTD O 201 and LYS O 100 |
Chain | Residue |
O | LEU98 |
O | GLY99 |
O | VAL101 |
O | THR102 |
S | LYS100 |
site_id | AD2 |
Number of Residues | 9 |
Details | binding site for Di-peptide PTD O 201 and LYS S 100 |
Chain | Residue |
N | GLY95 |
O | LEU98 |
O | GLY99 |
O | VAL101 |
O | THR102 |
S | LEU98 |
S | GLY99 |
S | VAL101 |
S | THR102 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for Di-peptide PTD S 701 and LYS S 75 |
Chain | Residue |
L | LYS355 |
S | ALA71 |
S | ARG72 |
S | ASP73 |
S | ASN74 |
S | LYS76 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for Di-peptide PTD S 701 and LYS L 355 |
Chain | Residue |
L | LEU352 |
L | ARG353 |
L | LEU354 |
L | PRO356 |
S | LYS75 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for Di-peptide PTD S 702 and LYS S 37 |
Chain | Residue |
P | LYS86 |
S | ARG33 |
S | LEU34 |
S | LEU35 |
S | ARG36 |
S | GLY38 |
S | ASN39 |
S | TYR40 |
site_id | AD6 |
Number of Residues | 14 |
Details | binding site for Di-peptide PTD S 702 and LYS P 86 |
Chain | Residue |
P | ALA82 |
P | HIS83 |
P | TYR84 |
P | ASN85 |
P | ARG87 |
S | LYS37 |
S | ARG82 |
S | HIS83 |
S | LEU84 |
S | GLN85 |
S | ALA87 |
S | ILE88 |
S | ARG89 |
S | ASN90 |
Functional Information from PROSITE/UniProt
site_id | PS00046 |
Number of Residues | 7 |
Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
Chain | Residue | Details |
C | ALA22-VAL28 |
site_id | PS00047 |
Number of Residues | 5 |
Details | HISTONE_H4 Histone H4 signature. GAKRH |
Chain | Residue | Details |
B | GLY15-HIS19 |
site_id | PS00357 |
Number of Residues | 23 |
Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
Chain | Residue | Details |
D | ARG93-GLY115 |
site_id | PS00959 |
Number of Residues | 9 |
Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
Chain | Residue | Details |
A | PRO67-ILE75 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
K | THR211 | |
L | THR211 | |
P | PRO2 | |
T | PRO2 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
K | SER213 | |
K | SER380 | |
K | LYS414 | |
L | SER213 | |
L | SER380 | |
L | LYS414 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:23722159, ECO:0000305|PubMed:26229115, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
K | GLU225 | |
H | LYS12 | |
H | LYS16 | |
H | LYS17 | |
H | LYS21 | |
H | LYS24 | |
H | LYS44 | |
H | LYS86 | |
P | LYS6 | |
P | LYS12 | |
P | LYS16 | |
K | ASP227 | |
P | LYS17 | |
P | LYS21 | |
P | LYS24 | |
P | LYS44 | |
P | LYS86 | |
T | LYS6 | |
T | LYS12 | |
T | LYS16 | |
T | LYS17 | |
T | LYS21 | |
L | GLU225 | |
T | LYS24 | |
T | LYS44 | |
T | LYS86 | |
L | ASP227 | |
D | LYS21 | |
D | LYS24 | |
D | LYS44 | |
D | LYS86 | |
H | LYS6 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
K | ASP319 | |
L | ASP319 | |
P | SER7 | |
T | SER7 | |
O | LYS10 | |
O | LYS96 | |
S | LYS10 | |
S | LYS96 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:31113940, ECO:0007744|PDB:4O67, ECO:0007744|PDB:6MJX |
Chain | Residue | Details |
K | LYS362 | |
R | LYS9 | |
R | LYS17 | |
R | LYS45 | |
K | ARG376 | |
L | LYS362 | |
L | ARG376 | |
F | LYS17 | |
F | LYS45 | |
N | LYS9 | |
N | LYS17 | |
N | LYS45 |
Chain | Residue | Details |
K | HIS390 | |
N | LYS32 | |
N | LYS78 | |
N | LYS92 | |
R | LYS13 | |
R | LYS32 | |
R | LYS78 | |
R | LYS92 | |
L | HIS390 | |
P | SER15 | |
T | SER15 | |
F | LYS13 | |
F | LYS32 | |
F | LYS78 | |
F | LYS92 | |
N | LYS13 |
Chain | Residue | Details |
K | CYS396 | |
K | CYS397 | |
K | CYS404 | |
L | CYS396 | |
L | CYS397 | |
L | CYS404 | |
S | LYS75 | |
S | LYS76 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:24462292, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
K | SER435 | |
T | LYS35 | |
T | LYS117 | |
T | LYS121 | |
L | SER435 | |
D | LYS121 | |
H | LYS35 | |
H | LYS117 | |
H | LYS121 | |
P | LYS35 | |
P | LYS117 | |
P | LYS121 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | SITE: Important for preferential detection of curved long DNA => ECO:0000269|PubMed:30007416 |
Chain | Residue | Details |
K | LYS187 | |
K | LEU195 | |
L | LYS187 | |
L | LEU195 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | SITE: Arginine-anchor => ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33051594 |
Chain | Residue | Details |
K | ARG255 | |
S | LYS119 | |
S | LYS120 | |
S | LYS126 | |
L | ARG255 | |
P | SER37 | |
T | SER37 | |
G | LYS120 | |
G | LYS126 | |
O | LYS119 | |
O | LYS120 | |
O | LYS126 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:30878284 |
Chain | Residue | Details |
K | ASP319 | |
L | ASP319 | |
H | LYS47 | |
H | LYS109 | |
P | LYS47 | |
P | LYS109 | |
T | LYS47 | |
T | LYS109 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: PolyADP-ribosyl aspartic acid => ECO:0000269|PubMed:35460603 |
Chain | Residue | Details |
K | ASP191 | |
L | ASP191 | |
P | LYS58 | |
T | LYS58 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | MOD_RES: (Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200 |
Chain | Residue | Details |
K | ASN210 | |
K | ASN389 | |
L | ASN210 | |
L | ASN389 | |
O | LYS120 | |
S | LYS120 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:33273464 |
Chain | Residue | Details |
K | SER213 | |
L | SER213 | |
H | ARG87 | |
H | ARG93 | |
P | ARG87 | |
P | ARG93 | |
T | ARG87 | |
T | ARG93 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine; by BLK => ECO:0000269|PubMed:30356214 |
Chain | Residue | Details |
K | TYR215 | |
L | TYR215 | |
P | THR116 | |
T | THR116 | |
N | LYS92 | |
R | LYS92 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
K | GLU286 | |
R | LYS21 | |
R | LYS60 | |
R | LYS80 | |
L | GLU286 | |
P | SER113 | |
T | SER113 | |
F | LYS60 | |
F | LYS80 | |
N | LYS21 | |
N | LYS60 | |
N | LYS80 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:33542149 |
Chain | Residue | Details |
K | SER305 | |
L | SER305 | |
P | LYS6 | |
T | LYS6 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | MOD_RES: 5-glutamyl glutamate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
K | GLU314 | |
L | GLU314 | |
H | LYS121 | |
P | LYS121 | |
T | LYS121 |
site_id | SWS_FT_FI19 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039 |
Chain | Residue | Details |
K | LYS384 | |
K | LYS392 | |
K | GLU394 | |
L | LYS384 | |
L | LYS392 | |
L | GLU394 |
site_id | SWS_FT_FI20 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039, ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
K | LYS414 | |
L | LYS414 | |
P | LYS35 | |
T | LYS35 |
site_id | SWS_FT_FI21 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700 |
Chain | Residue | Details |
K | SER434 | |
K | SER435 | |
L | SER434 | |
L | SER435 |
site_id | SWS_FT_FI22 |
Number of Residues | 4 |
Details | MOD_RES: (Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200 |
Chain | Residue | Details |
K | GLN451 | |
K | GLN454 | |
L | GLN451 | |
L | GLN454 |
site_id | SWS_FT_FI23 |
Number of Residues | 2 |
Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392 |
Chain | Residue | Details |
K | LYS506 | |
L | LYS506 |
site_id | SWS_FT_FI24 |
Number of Residues | 4 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:37802025 |
Chain | Residue | Details |
K | CYS404 | |
K | CYS405 | |
L | CYS404 | |
L | CYS405 |
site_id | SWS_FT_FI25 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:35438208 |
Chain | Residue | Details |
K | CYS474 | |
L | CYS474 |
site_id | SWS_FT_FI26 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28273161 |
Chain | Residue | Details |
K | LYS173 | |
L | LYS173 |
site_id | SWS_FT_FI27 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
K | LYS479 | |
L | LYS479 |
site_id | SWS_FT_FI28 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
K | LYS231 | |
L | LYS231 |
site_id | SWS_FT_FI29 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
K | LYS285 | |
L | LYS285 |
site_id | SWS_FT_FI30 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
K | LYS347 | |
L | LYS347 |
site_id | SWS_FT_FI31 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:28273161 |
Chain | Residue | Details |
K | LYS384 | |
L | LYS384 |
site_id | SWS_FT_FI32 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
K | GLU394 | |
L | GLU394 |
site_id | SWS_FT_FI33 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:35503863 |
Chain | Residue | Details |
K | LYS411 | |
L | LYS411 |
site_id | SWS_FT_FI34 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27666593 |
Chain | Residue | Details |
K | LYS414 | |
L | LYS414 |
site_id | SWS_FT_FI35 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:38418882 |
Chain | Residue | Details |
K | LYS427 | |
K | LYS428 | |
L | LYS427 | |
L | LYS428 |