6Y4Y

The crystal structure of human MACROD2 in space group P41212

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thioredoxin 1,ADP-ribose glycohydrolase MACROD2	polymer	366	40906.8	4	UniProt (P0AA25) UniProt (A1Z1Q3) Pfam (PF00085) Pfam (PF01661)	Escherichia coli (strain K12)	Trx-1,MACRO domain-containing protein 2,O-acetyl-ADP-ribose deacetylase MACROD2,[Protein ADP-ribosylaspartate] hydrolase MACROD2,[Protein ADP-ribosylglutamate] hydrolase MACROD2
2	E (B)	L(+)-TARTARIC ACID	non-polymer		150.1	1	Chemie (TLA)
3	F, G, H, I (A, B, C, D)	water	water		18.0	511	Chemie (HOH)

Sequence modifications

A, B, C, D: -112 - -4 (UniProt: P0AA25)

PDB	External Database	Details
Met -122	-	initiating methionine
His -121	-	expression tag
His -120	-	expression tag
His -119	-	expression tag
His -118	-	expression tag
His -117	-	expression tag
His -116	-	expression tag
Ser -115	-	expression tag
Ser -114	-	expression tag
Gly -113	-	expression tag
Gly -3	-	linker
Thr -2	-	linker
Glu -1	-	linker
Asn 0	-	linker
Leu 1	-	linker
Tyr 2	-	linker
Phe 3	-	linker
Gln 4	-	linker
Ser 5	-	linker
Met 6	-	linker

A, B, C, D: 7 - 243 (UniProt: A1Z1Q3)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	163627.4
Non-Polymers*	Number of molecules	1
	Total formula weight	150.1
All*	Total formula weight	163777.5

*Water molecules are not included.