6Y4L

Crystal structure of human ER membrane protein complex subunits EMC2 and EMC9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ER membrane protein complex subunit 2	polymer	275	32352.6	1	UniProt (Q15006) Pfam (PF22890)	Homo sapiens (Human)	Tetratricopeptide repeat protein 35,TPR repeat protein 35
2	B (B)	ER membrane protein complex subunit 9	polymer	212	23781.3	1	UniProt (Q9Y3B6) Pfam (PF03665)	Homo sapiens (Human)	Protein FAM158A
3	C, D, I (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	E, F, J (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	G (A)	2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL	non-polymer		354.4	1	Chemie (PE4)
6	H, K, L (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
7	M, N (A, B)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 11 - 274 (UniProt: Q15006)

PDB	External Database	Details
Met 10	-	initiating methionine
Ala 275	-	expression tag
Ala 276	-	expression tag
Ala 277	-	expression tag
Leu 278	-	expression tag
Glu 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag

B: 1 - 200 (UniProt: Q9Y3B6)

PDB	External Database	Details
Ala 201	-	expression tag
Ala 202	-	expression tag
Ala 203	-	expression tag
Leu 204	-	expression tag
Glu 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56133.8
Non-Polymers*	Number of molecules	10
	Total formula weight	1147.2
All*	Total formula weight	57281.0

*Water molecules are not included.