6Y1Z
Mouse serotonin 5HT3 receptor in complex with palonosetron
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, B, C, E | 5-hydroxytryptamine receptor 3A | polymer | 566 | 63682.7 | 5 | UniProt (P23979) Pfam (PF02931) Pfam (PF02932) In PDB | Mus musculus (house mouse) | 5-HT3-A,5-HT3A,5-hydroxytryptamine receptor 3,5-HT-3,5-HT3R,Serotonin receptor 3A,Serotonin-gated ion channel receptor |
| 2 | F, H, J, L, N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 3 | G, I, K, M, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | C, E, A, D, B | TRYPTOPHAN | non-polymer | 204.2 | 5 | Chemie (TRP) | |||
| 5 | C, E, A, D, B | HISTIDINE | non-polymer | 156.2 | 5 | Chemie (HIS) | |||
| 6 | C, E, A, D, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 7 | B, C, E, A, D | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one | non-polymer | 296.4 | 5 | Chemie (O7B) |
Sequence modifications
A, D, B, C, E: 6 - 460 (UniProt: P23979)
| PDB | External Database | Details |
|---|---|---|
| Met -103 | - | initiating methionine |
| Arg -102 | - | expression tag |
| Leu -101 | - | expression tag |
| Cys -100 | - | expression tag |
| Ile -99 | - | expression tag |
| Pro -98 | - | expression tag |
| Gln -97 | - | expression tag |
| Val -96 | - | expression tag |
| Leu -95 | - | expression tag |
| Leu -94 | - | expression tag |
| Ala -93 | - | expression tag |
| Leu -92 | - | expression tag |
| Phe -91 | - | expression tag |
| Leu -90 | - | expression tag |
| Ser -89 | - | expression tag |
| Met -88 | - | expression tag |
| Leu -87 | - | expression tag |
| Thr -86 | - | expression tag |
| Gly -85 | - | expression tag |
| Pro -84 | - | expression tag |
| Gly -83 | - | expression tag |
| Glu -82 | - | expression tag |
| Gly -81 | - | expression tag |
| Ser -80 | - | expression tag |
| Arg -79 | - | expression tag |
| Arg -78 | - | expression tag |
| Arg -77 | - | expression tag |
| Trp -76 | - | expression tag |
| Ser -75 | - | expression tag |
| His -74 | - | expression tag |
| Pro -73 | - | expression tag |
| Gln -72 | - | expression tag |
| Phe -71 | - | expression tag |
| Glu -70 | - | expression tag |
| Lys -69 | - | expression tag |
| Gly -68 | - | expression tag |
| Gly -67 | - | expression tag |
| Gly -66 | - | expression tag |
| Ser -65 | - | expression tag |
| Gly -64 | - | expression tag |
| Gly -63 | - | expression tag |
| Gly -62 | - | expression tag |
| Ser -61 | - | expression tag |
| Gly -60 | - | expression tag |
| Gly -59 | - | expression tag |
| Gly -58 | - | expression tag |
| Ser -57 | - | expression tag |
| Trp -56 | - | expression tag |
| Ser -55 | - | expression tag |
| His -54 | - | expression tag |
| Pro -53 | - | expression tag |
| Gln -52 | - | expression tag |
| Phe -51 | - | expression tag |
| Glu -50 | - | expression tag |
| Lys -49 | - | expression tag |
| Gly -48 | - | expression tag |
| Gly -47 | - | expression tag |
| Gly -46 | - | expression tag |
| Ser -45 | - | expression tag |
| Gly -44 | - | expression tag |
| Gly -43 | - | expression tag |
| Gly -42 | - | expression tag |
| Ser -41 | - | expression tag |
| Gly -40 | - | expression tag |
| Gly -39 | - | expression tag |
| Gly -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Trp -36 | - | expression tag |
| Ser -35 | - | expression tag |
| His -34 | - | expression tag |
| Pro -33 | - | expression tag |
| Gln -32 | - | expression tag |
| Phe -31 | - | expression tag |
| Glu -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Gly -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Trp -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Phe -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Gln 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Arg 5 | - | expression tag |
| Ala 277 | - | insertion |
| Ser 461 | - | expression tag |
| Ser 462 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 318413.6 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5054.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4390.0 | |
| All* | Total formula weight | 327858.3 |
