6Y0A
CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH BI00690300
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cyclin-dependent kinase 8 | polymer | 406 | 47105.9 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
2 | B | Cyclin-C | polymer | 283 | 33292.8 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
3 | A | 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide | non-polymer | 332.8 | 1 | Chemie (JRE) | |||
4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | B | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
6 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 280 (UniProt: P24863)
PDB | External Database | Details |
---|---|---|
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -2 | - | expression tag |
Lys -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 80398.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 532.9 | |
All* | Total formula weight | 80931.6 |