6XZ7
E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 23S rRNA | polymer | 2897 | 939609.3 | 1 | Escherichia coli (strain K12) | ||
| 2 | B (B) | 5S rRNA | polymer | 120 | 38790.1 | 1 | Escherichia coli (strain K12) | ||
| 3 | C (C) | 50S ribosomal protein L2 | polymer | 271 | 29663.2 | 1 | UniProt (P60422) Pfam (PF00181) Pfam (PF03947) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL2 |
| 4 | D (D) | 50S ribosomal protein L3 | polymer | 209 | 22291.6 | 1 | UniProt (P60438) Pfam (PF00297) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL3 |
| 5 | E (E) | 50S ribosomal protein L4 | polymer | 201 | 22121.6 | 1 | UniProt (P60723) Pfam (PF00573) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL4 |
| 6 | F (F) | 50S ribosomal protein L5 | polymer | 177 | 20073.2 | 1 | UniProt (P62399) Pfam (PF00281) Pfam (PF00673) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL5 |
| 7 | G (G) | 50S ribosomal protein L6 | polymer | 176 | 18801.6 | 1 | UniProt (P0AG55) Pfam (PF00347) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL6 |
| 8 | H (H) | 50S ribosomal protein L10 | polymer | 135 | 14568.7 | 1 | UniProt (P0A7J3) Pfam (PF00466) | Escherichia coli (strain K12) | 50S ribosomal protein L8,Large ribosomal subunit protein uL10 |
| 9 | I (I) | 50S ribosomal protein L11 | polymer | 134 | 14020.3 | 1 | UniProt (P0A7J7) Pfam (PF03946) Pfam (PF00298) | Escherichia coli (strain K12) | |
| 10 | J (J) | 50S ribosomal protein L13 | polymer | 142 | 16050.6 | 1 | UniProt (P0AA10) Pfam (PF00572) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL13 |
| 11 | K (K) | 50S ribosomal protein L14 | polymer | 123 | 13565.1 | 1 | UniProt (P0ADY3) Pfam (PF00238) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL14 |
| 12 | L (L) | 50S ribosomal protein L15 | polymer | 144 | 15008.5 | 1 | UniProt (P02413) Pfam (PF00828) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL15 |
| 13 | M (M) | 50S ribosomal protein L16 | polymer | 136 | 15327.3 | 1 | UniProt (P0ADY7) Pfam (PF00252) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL16 |
| 14 | N (N) | 50S ribosomal protein L17 | polymer | 125 | 14193.5 | 1 | UniProt (P0AG44) Pfam (PF01196) | Escherichia coli (strain K12) | |
| 15 | O (O) | 50S ribosomal protein L18 | polymer | 117 | 12794.7 | 1 | UniProt (P0C018) Pfam (PF00861) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL18 |
| 16 | P (P) | 50S ribosomal protein L19 | polymer | 114 | 13028.1 | 1 | UniProt (P0A7K6) Pfam (PF01245) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL19 |
| 17 | Q (Q) | 50S ribosomal protein L20 | polymer | 117 | 13396.8 | 1 | UniProt (P0A7L3) Pfam (PF00453) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL20 |
| 18 | R (R) | 50S ribosomal protein L21 | polymer | 103 | 11586.4 | 1 | UniProt (P0AG48) Pfam (PF00829) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL21 |
| 19 | S (S) | 50S ribosomal protein L22 | polymer | 110 | 12253.4 | 1 | UniProt (P61175) Pfam (PF00237) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL22 |
| 20 | T (T) | 50S ribosomal protein L23 | polymer | 93 | 10546.5 | 1 | UniProt (P0ADZ0) Pfam (PF00276) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL23 |
| 21 | U (U) | 50S ribosomal protein L24 | polymer | 102 | 11078.9 | 1 | UniProt (P60624) Pfam (PF00467) Pfam (PF17136) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL24 |
| 22 | V (V) | 50S ribosomal protein L25 | polymer | 94 | 10713.5 | 1 | UniProt (P68919) Pfam (PF01386) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL25 |
| 23 | W (W) | 50S ribosomal protein L27 | polymer | 76 | 8275.5 | 1 | UniProt (P0A7L8) Pfam (PF01016) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL27 |
| 24 | X (X) | 50S ribosomal protein L28 | polymer | 77 | 8896.4 | 1 | UniProt (P0A7M2) Pfam (PF00830) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL28 |
| 25 | Y (Y) | 50S ribosomal protein L29 | polymer | 62 | 7155.3 | 1 | UniProt (P0A7M6) Pfam (PF00831) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL29 |
| 26 | Z (Z) | 50S ribosomal protein L30 | polymer | 58 | 6423.6 | 1 | UniProt (P0AG51) Pfam (PF00327) | Escherichia coli (strain K12) | Large ribosomal subunit protein uL30 |
| 27 | AA (a) | 50S ribosomal protein L32 | polymer | 56 | 6332.2 | 1 | UniProt (P0A7N4) Pfam (PF01783) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL32 |
| 28 | BA (b) | 50S ribosomal protein L33 | polymer | 51 | 5928.0 | 1 | UniProt (P0A7N9) Pfam (PF00471) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL33 |
| 29 | CA (c) | 50S ribosomal protein L34 | polymer | 46 | 5397.5 | 1 | UniProt (P0A7P5) Pfam (PF00468) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL34 |
| 30 | DA (d) | 50S ribosomal protein L35 | polymer | 64 | 7181.8 | 1 | UniProt (P0A7Q1) Pfam (PF01632) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL35,Ribosomal protein A |
| 31 | EA (e) | 50S ribosomal protein L36 | polymer | 38 | 4377.4 | 1 | UniProt (P0A7Q6) Pfam (PF00444) | Escherichia coli (strain K12) | Large ribosomal subunit protein bL36-A,Ribosomal protein B |
| 32 | FA (f) | Deacylated tRNAi(Met) | polymer | 76 | 24541.7 | 1 | GenBank (745369752) | Escherichia coli (strain K12) | |
| 33 | GA (g) | fMet-Phe-tRNA(Phe) | polymer | 76 | 25167.5 | 1 | Saccharomyces cerevisiae (baker's yeast) | ||
| 34 | AB, AC, AD, AE, AF... (A, B, U) | MAGNESIUM ION | non-polymer | 24.3 | 178 | Chemie (MG) PubChem (888) | |||
| 35 | ZG (A) | Dirithromycin | non-polymer | 835.1 | 1 | Chemie (DI0) PubChem (22525198) PubChem (177580083) PubChem (16395004) PubChem (16757842) PubChem (18397681) PubChem (23307237) PubChem (44335638) PubChem (45105094) PubChem (46705321) PubChem (46783780) PubChem (70789200) PubChem (71312364) PubChem (462481) PubChem (78358338) PubChem (89969215) PubChem (5464388) PubChem (6473883) PubChem (6604422) PubChem (6917067) PubChem (124605128) PubChem (124748242) PubChem (124748238) PubChem (124748240) PubChem (124865143) PubChem (124870686) PubChem (124939401) PubChem (129009904) PubChem (129010302) PubChem (132274080) PubChem (12986425) PubChem (137965484) PubChem (138107815) PubChem (154825134) PubChem (168322458) PubChem (60148420) PubChem (71306790) PubChem (71729967) PubChem (112547091) PubChem (124748235) PubChem (124748236) PubChem (124748237) PubChem (124748239) PubChem (124748241) PubChem (4580358) PubChem (124939402) PubChem (6713946) PubChem (126968498) PubChem (129009964) PubChem (129010005) PubChem (9811215) PubChem (9988071) PubChem (129119818) PubChem (129629095) PubChem (132274085) PubChem (133688194) PubChem (134693953) PubChem (146159353) PubChem (164186513) PubChem (171360037) | |||
| 36 | EH, FH, GH, HH, IH... (A, B, C, D, E...) | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
H: 2 - 136 (UniProt: P0A7J3)
| PDB | External Database | Details |
|---|---|---|
| Val 85 | Ser 85 | conflict |
| Thr 86 | Met 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 33 |
| Total formula weight | 1399159.5 | |
| Non-Polymers* | Number of molecules | 179 |
| Total formula weight | 5161.4 | |
| All* | Total formula weight | 1404320.9 |
