6XWG
Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RARb2 DR5 Response Element, 5'-3' strand | polymer | 21 | 6447.2 | 1 | Homo sapiens | ||
| 2 | B (B) | RARb2 DR5 Response Element, 3'-5' strand | polymer | 21 | 6438.2 | 1 | Homo sapiens | ||
| 3 | C (C) | Retinoic acid receptor RXR-alpha | polymer | 87 | 10262.9 | 1 | UniProt (P19793) Pfam (PF00105) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 4 | D (D) | Retinoic acid receptor alpha | polymer | 90 | 10633.5 | 1 | UniProt (P10276) Pfam (PF00105) | Homo sapiens (Human) | RAR-alpha,Nuclear receptor subfamily 1 group B member 1 |
| 5 | E, F, I, J (C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | G (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | H (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
C: 130 - 212 (UniProt: P19793)
D: 82 - 167 (UniProt: P10276)
| PDB | External Database | Details |
|---|---|---|
| Gly 126 | - | expression tag |
| Ser 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| His 80 | - | expression tag |
| Met 81 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 33781.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 389.2 | |
| All* | Total formula weight | 34170.9 |
