6XUG
Human Ecto-5'-nucleotidase (CD73) in complex with A2410 (compound 53 in publication) in the closed form in crystal form IV
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 5'-nucleotidase | polymer | 538 | 59444.5 | 2 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) In PDB | Homo sapiens (Human) | 5'-NT,Ecto-5'-nucleotidase |
2 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
4 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
5 | A, B | 4-chloranyl-1-(1~{H}-indazol-6-yl)-6-[2-(3-methylphenyl)pyrazol-3-yl]benzotriazole | non-polymer | 425.9 | 2 | Chemie (O1Q) | |||
6 | water | water | 18.0 | 845 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 549 (UniProt: P21589)
PDB | External Database | Details |
---|---|---|
Asp 53 | Asn 53 | conflict |
Asp 311 | Asn 311 | conflict |
Asp 333 | Asn 333 | conflict |
Asp 403 | Asn 403 | conflict |
Gly 550 | - | expression tag |
Gly 551 | - | expression tag |
Gly 552 | - | expression tag |
Gly 553 | - | expression tag |
Ala 554 | - | expression tag |
Gly 555 | - | expression tag |
Gly 556 | - | expression tag |
Gly 557 | - | expression tag |
Gly 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
His 562 | - | expression tag |
His 563 | - | expression tag |
His 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 118889.0 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1383.5 | |
All* | Total formula weight | 120272.4 |