6XU1
Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with GTP, dAMPNPP and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60141.7 | 8 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | AB, EA, HB, I, LA... (G, D, H, A, E...) | FE (III) ION | non-polymer | 55.8 | 8 | Chemie (FE) | |||
| 3 | BB, CB, DB, FA, GA... (G, D, H, A, E...) | MAGNESIUM ION | non-polymer | 24.3 | 25 | Chemie (MG) | |||
| 4 | AA, CA, DA, EB, GB... (C, D, G, H, A...) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 490.2 | 16 | Chemie (DZ4) | |||
| 5 | BA, FB, JA, MB, N... (C, G, D, H, A...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 8 | Chemie (GTP) | |||
| 6 | NB, OB, PB, QB, RB... (A, B, C, D, E...) | water | water | 18.0 | 796 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Ala 215 | His 215 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 481133.9 | |
| Non-Polymers* | Number of molecules | 57 |
| Total formula weight | 13083.0 | |
| All* | Total formula weight | 494216.9 |
