6XP9
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide IN COMPLEX WITH (S,S)-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion | polymer | 351 | 39895.6 | 2 | UniProt (O75469) UniProt (Q15788) Pfam (PF00104) Pfam (PF08832) In PDB | Homo sapiens (Human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
2 | A, B | (2S)-tert-butoxy[7-(8-fluoro-5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid | non-polymer | 503.6 | 2 | Chemie (QCG) | |||
3 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 434 (UniProt: O75469)
A, B: 441 - 473 (UniProt: Q15788)
PDB | External Database | Details |
---|---|---|
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
Gly 129 | - | expression tag |
Ser 435 | - | linker |
Gly 436 | - | linker |
Gly 437 | - | linker |
Ser 438 | - | linker |
Gly 439 | - | linker |
Gly 440 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79791.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1099.2 | |
All* | Total formula weight | 80890.5 |