6XOV

CryoEM structure of human presequence protease in partial closed state 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Presequence protease, mitochondrial	polymer	1014	114901.5	1	UniProt (Q5JRX3) Pfam (PF00675) Pfam (PF05193) Pfam (PF08367) Pfam (PF22516) In PDB	Homo sapiens (Human)	hPreP,Pitrilysin metalloproteinase 1,hMP1
2	B	Amyloid-beta precursor protein	polymer	40	4335.9	1	UniProt (P05067) Pfam (PF03494) In PDB	Homo sapiens	APP,ABPP,APPI,Alzheimer disease amyloid protein,Amyloid precursor protein,Amyloid-beta A4 protein,Cerebral vascular amyloid peptide,CVAP,PreA4,Protease nexin-II,PN-II
3	C	Amyloid-beta precursor protein	polymer	3	273.3	1		Homo sapiens

Sequence modifications

A: 33 - 1037 (UniProt: Q5JRX3)

PDB	External Database	Details
Met 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
Ala 31	-	expression tag
Ala 32	-	expression tag
Val 328	Ile 328	conflict
Val 397	Ala 397	conflict
Arg 1037	Gln 1037	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	119510.6
All*	Total formula weight	119510.6

*Water molecules are not included.