6XOV
CryoEM structure of human presequence protease in partial closed state 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Presequence protease, mitochondrial | polymer | 1014 | 114901.5 | 1 | UniProt (Q5JRX3) Pfam (PF00675) Pfam (PF05193) Pfam (PF08367) Pfam (PF22516) | Homo sapiens (Human) | hPreP,Pitrilysin metalloproteinase 1,hMP1 |
| 2 | B (B) | Amyloid-beta precursor protein | polymer | 40 | 4335.9 | 1 | UniProt (P05067) Pfam (PF03494) | Homo sapiens | APP,ABPP,APPI,Alzheimer disease amyloid protein,Amyloid precursor protein,Amyloid-beta A4 protein,Cerebral vascular amyloid peptide,CVAP,PreA4,Protease nexin-II,PN-II |
| 3 | C (C) | Amyloid-beta precursor protein | polymer | 3 | 273.3 | 1 | Homo sapiens |
Sequence modifications
A: 33 - 1037 (UniProt: Q5JRX3)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| His 29 | - | expression tag |
| His 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Val 328 | Ile 328 | conflict |
| Val 397 | Ala 397 | conflict |
| Arg 1037 | Gln 1037 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 119510.6 | |
| All* | Total formula weight | 119510.6 |
