6XOV
CryoEM structure of human presequence protease in partial closed state 1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006508 | biological_process | proteolysis |
A | 0006626 | biological_process | protein targeting to mitochondrion |
A | 0008047 | molecular_function | enzyme activator activity |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0016485 | biological_process | protein processing |
A | 0046872 | molecular_function | metal ion binding |
B | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
B | GLY25 | |
B | GLY33 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
Chain | Residue | Details |
B | GLY29 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
B | ILE32 | |
A | HIS108 | |
A | GLU205 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Cleavage; by beta-secretase => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
B | PHE19 | |
A | LYS884 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
Chain | Residue | Details |
B | PHE20 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
Chain | Residue | Details |
B | SER26 | |
A | LYS946 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
B | MET35 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
Chain | Residue | Details |
B | GLY38 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms => ECO:0000269|PubMed:21712440 |
Chain | Residue | Details |
B | PHE4 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (HexNAc...) threonine; partial => ECO:0000269|PubMed:22576872 |
Chain | Residue | Details |
B | ASP7 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
Chain | Residue | Details |
B | GLU11 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
Chain | Residue | Details |
B | GLN15 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
Chain | Residue | Details |
B | GLY29 |