6XKI
Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic initiation factor 4A-I | polymer | 389 | 44340.9 | 1 | UniProt (P60843) Pfam (PF00270) Pfam (PF00271) | Mus musculus (Mouse) | eIF4A-I,ATP-dependent RNA helicase eIF4A-1 |
| 2 | B (B) | RNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3') | polymer | 10 | 3327.1 | 1 | synthetic construct | ||
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione | non-polymer | 541.7 | 1 | Chemie (V6D) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 19 - 406 (UniProt: P60843)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47668.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1072.2 | |
| All* | Total formula weight | 48740.2 |
