6XHB
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 170 | 19328.8 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (B) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 137 | 15888.4 | 1 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) | Homo sapiens (Human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E, F, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | G, L (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | H (B) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 8 | I, J (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 9 | M, N (A, B) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35217.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1028.0 | |
| All* | Total formula weight | 36245.2 |
