6XDS
Crystal structure of MBP-TREM2 Ig domain fusion with fragment, 2-((4-bromophenyl)amino)ethan-1-ol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sugar ABC transporter substrate-binding protein,Triggering receptor expressed on myeloid cells 2 | polymer | 492 | 54172.1 | 1 | UniProt (A0A0F8NYV9) UniProt (Q9NZC2) Pfam (PF01547) Pfam (PF07686) UniProt (by SIFTS) (P0AEX9) In PDB | Methanosarcina mazei | TREM-2,Triggering receptor expressed on monocytes 2 |
2 | B | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 504.4 | 1 | In PDB BIRD (PRD_900009) GlyTouCan (G96370VA) | alpha-maltotriose | ||
3 | A | 2-[(4-bromophenyl)amino]ethan-1-ol | non-polymer | 216.1 | 1 | Chemie (V5S) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
5 | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
A: 1 - 367 (UniProt: A0A0F8NYV9)
A: 368 - 485 (UniProt: Q9NZC2)
PDB | External Database | Details |
---|---|---|
Ala 82 | Asp 83 | conflict |
Ala 83 | Lys 84 | conflict |
Ala 172 | Glu 173 | conflict |
Ala 173 | Asn 174 | conflict |
His 215 | Ala 216 | conflict |
His 219 | Lys 220 | conflict |
Ala 239 | Lys 240 | conflict |
Val 312 | Ala 313 | conflict |
Val 317 | Ile 318 | conflict |
Ala 359 | Glu 360 | conflict |
Ala 362 | Lys 363 | conflict |
Ala 363 | Asp 364 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 370 | Asn 20 | conflict |
His 486 | - | expression tag |
His 487 | - | expression tag |
His 488 | - | expression tag |
His 489 | - | expression tag |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54172.1 | |
Branched | Number of molecules | 1 |
Total formula weight | 504.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 450.5 | |
All* | Total formula weight | 55127.0 |