6XBL
Structure of human SMO-Gi complex with SAG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Smoothened homolog | polymer | 652 | 71786.4 | 1 | UniProt (Q99835) Pfam (PF01392) Pfam (PF01534) | Homo sapiens (Human) | SMO,Protein Gx |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (S) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 6 | F (R) | 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide | non-polymer | 490.1 | 1 | Chemie (V0S) | |||
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
R: 1 - 644 (UniProt: Q99835)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp 645 | - | expression tag |
| Tyr 646 | - | expression tag |
| Lys 647 | - | expression tag |
| Asp 648 | - | expression tag |
| Asp 649 | - | expression tag |
| Asp 650 | - | expression tag |
| Asp 651 | - | expression tag |
| Lys 652 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 185518.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 876.7 | |
| All* | Total formula weight | 186395.3 |
