6XA9
SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Non-structural protein 3 | polymer | 318 | 35982.9 | 3 | UniProt (P0DTD1) Pfam (PF08715) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp3,PL2-PRO,Papain-like protease,Papain-like proteinase,PL-PRO |
| 2 | B, D, F | ISG15 CTD-propargylamide | polymer | 80 | 9024.3 | 3 | UniProt (P05161) Pfam (PF00240) In PDB | Homo sapiens (Human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 3 | A, C, E | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 4 | A, C, E | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, C, E: 0 - 315 (UniProt: P0DTD1)
B, D, F: 79 - 157 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 78 | - | initiating methionine |
| Aye 157 | Gly 157 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 135021.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 933.0 | |
| All* | Total formula weight | 135954.6 |
