6XA9

SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue GOL A 401

Chain	Residue
A	HIS73
A	ASN128
A	GLN174
A	HIS175

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 402

Chain	Residue
A	HIS47
A	ASN48
A	SER49

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 403

Chain	Residue
A	THR63
A	LEU64
A	GLN19
A	ASP61

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 404

Chain	Residue
A	CYS189
A	CYS192
A	CYS224
A	CYS226

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL C 401

Chain	Residue
C	HIS73
C	ASN128
C	PRO129
C	GLN174
C	HIS175

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL C 402

Chain	Residue
C	HIS47
C	ASN48
C	SER49

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL C 403

Chain	Residue
C	HIS17
C	GLN19
C	ASP61
C	THR63
C	LEU64

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 404

Chain	Residue
C	CYS189
C	CYS192
C	CYS224
C	CYS226

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS189
E	CYS192
E	CYS224
E	CYS226

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL E 502

Chain	Residue
A	SER294
E	LEU16
E	HIS17

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL E 503

Chain	Residue
E	HIS73
E	ASN128
E	PRO129
E	GLN174
E	HIS175

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Interacts with activating enzyme => ECO:0000250

Chain	Residue	Details
D	ARG153
F	ARG153
B	ARG153

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
C	CYS111
D	AYE157
F	AYE157
B	AYE157

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
C	ASP286
E	HIS272
E	ASP286
A	ASP286
C	HIS272
A	HIS272

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189
A	CYS192
A	CYS224
A	CYS226
C	CYS189
C	CYS192
C	CYS224
C	CYS226
E	CYS189
E	CYS192
E	CYS224
E	CYS226

---