6XA9
SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | HIS73 |
| A | ASN128 |
| A | GLN174 |
| A | HIS175 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | HIS47 |
| A | ASN48 |
| A | SER49 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | THR63 |
| A | LEU64 |
| A | GLN19 |
| A | ASP61 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 404 |
| Chain | Residue |
| A | CYS189 |
| A | CYS192 |
| A | CYS224 |
| A | CYS226 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 401 |
| Chain | Residue |
| C | HIS73 |
| C | ASN128 |
| C | PRO129 |
| C | GLN174 |
| C | HIS175 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | HIS47 |
| C | ASN48 |
| C | SER49 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | HIS17 |
| C | GLN19 |
| C | ASP61 |
| C | THR63 |
| C | LEU64 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 404 |
| Chain | Residue |
| C | CYS189 |
| C | CYS192 |
| C | CYS224 |
| C | CYS226 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 501 |
| Chain | Residue |
| E | CYS189 |
| E | CYS192 |
| E | CYS224 |
| E | CYS226 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 502 |
| Chain | Residue |
| A | SER294 |
| E | LEU16 |
| E | HIS17 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 503 |
| Chain | Residue |
| E | HIS73 |
| E | ASN128 |
| E | PRO129 |
| E | GLN174 |
| E | HIS175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | Domain: {"description":"Ubiquitin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 111 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32726803","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
