6X8F
Crystal structure of TYK2 with Compound 11
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Non-receptor tyrosine-protein kinase TYK2 | polymer | 318 | 36550.6 | 2 | UniProt (P29597) Pfam (PF07714) In PDB | Homo sapiens (Human) | |
2 | A, C | [3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | non-polymer | 441.4 | 2 | Chemie (UWP) | |||
3 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, C: 888 - 1182 (UniProt: P29597)
PDB | External Database | Details |
---|---|---|
Met 865 | - | expression tag |
Ala 866 | - | expression tag |
His 867 | - | expression tag |
His 868 | - | expression tag |
His 869 | - | expression tag |
His 870 | - | expression tag |
His 871 | - | expression tag |
His 872 | - | expression tag |
His 873 | - | expression tag |
His 874 | - | expression tag |
His 875 | - | expression tag |
His 876 | - | expression tag |
Gly 877 | - | expression tag |
Ala 878 | - | expression tag |
Leu 879 | - | expression tag |
Glu 880 | - | expression tag |
Val 881 | - | expression tag |
Leu 882 | - | expression tag |
Phe 883 | - | expression tag |
Gln 884 | - | expression tag |
Gly 885 | - | expression tag |
Pro 886 | - | expression tag |
Gly 887 | - | expression tag |
Ala 936 | Cys 936 | engineered mutation |
Ala 969 | Gln 969 | engineered mutation |
Ala 971 | Glu 971 | engineered mutation |
Ala 972 | Lys 972 | engineered mutation |
Ser 1016 | Ala 1016 | engineered mutation |
Ala 1142 | Cys 1142 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73101.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 882.8 | |
All* | Total formula weight | 73984.0 |