6X8F

Crystal structure of TYK2 with Compound 11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue UWP A 4001

Chain	Residue
A	LEU903
A	PRO982
A	GLY984
A	ARG1027
A	ASN1028
A	LEU1030
A	GLY1040
A	ASP1041
A	HOH4129
A	HOH4157
A	HOH4186
A	GLY906
A	GLY909
A	LYS910
A	VAL911
A	ALA928
A	LYS930
A	TYR980
A	VAL981

---

site_id	AC2
Number of Residues	20
Details	binding site for residue UWP C 4000

Chain	Residue
C	LEU903
C	GLY904
C	GLY906
C	GLY909
C	LYS910
C	VAL911
C	ALA928
C	LYS930
C	ILE960
C	GLU979
C	TYR980
C	VAL981
C	PRO982
C	GLY984
C	ARG1027
C	ASN1028
C	LEU1030
C	GLY1040
C	ASP1041
C	HOH4170

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGHFGKVSlYcydptndgtgem......VAVK

Chain	Residue	Details
A	LEU903-LYS930

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLAARNVLL

Chain	Residue	Details
A	TYR1019-LEU1031

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"20478313","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8702790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8702790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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