6X5Q
Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluA1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calcium/calmodulin-dependent protein kinase type II subunit alpha | polymer | 268 | 30548.1 | 1 | UniProt (Q9UQM7) Pfam (PF00069) | Homo sapiens (Human) | CaMK-II subunit alpha |
| 2 | B (B) | Glutamate receptor 1 | polymer | 20 | 2323.8 | 1 | UniProt (P42261) | Homo sapiens | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 3 | C, D, E (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 7 - 274 (UniProt: Q9UQM7)
| PDB | External Database | Details |
|---|---|---|
| Asn 135 | Asp 135 | engineered mutation |
| Lys 223 | Gln 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32871.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 33148.1 |
