6X5Q

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluA1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 301

Chain	Residue
A	ARG104
A	TYR106
A	SER108

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site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU96
A	PHE98
A	GLU99
A	GLU139
A	HOH426
A	HOH478

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL B 901

Chain	Residue
A	TRP214
A	HOH442
B	CYS825
B	LEU826
B	ILE827
B	GLN829
B	HOH1010

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFSVVRrCvkvlagqe..........YAAK

Chain	Residue	Details
A	LEU19-LYS42

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19490

Chain	Residue	Details
B	MET821
B	ALA835

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU19
A	LYS42

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P11798

Chain	Residue	Details
A	TYR13

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11275

Chain	Residue	Details
A	SER257

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