6X4T
Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | ICOS ligand | polymer | 240 | 26771.8 | 2 | UniProt (O75144) Pfam (PF07686) Pfam (PF22705) | Homo sapiens (Human) | B7 homolog 2,B7-H2,B7-like protein Gl50,B7-related protein 1,B7RP-1 |
| 2 | B, D (B, D) | Prezalumab Fab Heavy chain | polymer | 224 | 24001.0 | 2 | Homo sapiens | ||
| 3 | E, F (E, F) | Prezalumab Fab Light chain | polymer | 214 | 23456.9 | 2 | Homo sapiens | ||
| 4 | G, H (G, N) | VNAR | polymer | 130 | 13987.4 | 2 | Orectolobus maculatus | ||
| 5 | I, J (H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, L, M, N, O... (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 7 | P, U (A, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) |
Sequence modifications
A, C: 19 - 248 (UniProt: O75144)
| PDB | External Database | Details |
|---|---|---|
| Thr 17 | - | cloning artifact |
| Gly 18 | - | cloning artifact |
| Gly 249 | - | expression tag |
| Thr 250 | - | expression tag |
| Glu 251 | - | expression tag |
| Asn 252 | - | expression tag |
| Leu 253 | - | expression tag |
| Tyr 254 | - | expression tag |
| Phe 255 | - | expression tag |
| Gln 256 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 176434.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2175.1 | |
| All* | Total formula weight | 179458.1 |
