6X4I

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with 3'-uridinemonophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Uridylate-specific endoribonuclease	polymer	370	41657.2	2	UniProt (P0DTD1) Pfam (PF19219) Pfam (PF19216) Pfam (PF19215) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP15 endoribnuclease
2	A, B	3'-URIDINEMONOPHOSPHATE	non-polymer		324.2	2	Chemie (U3P)
3	A, B	1,2-ETHANEDIOL	non-polymer		62.1	20	Chemie (EDO)
4	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5		water	water		18.0	718	Chemie (HOH)

Sequence modifications

A, B: 2 - 347 (UniProt: P0DTD1)

PDB	External Database	Details
Met -22	-	initiating methionine
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Val -12	-	expression tag
Asp -11	-	expression tag
Leu -10	-	expression tag
Gly -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
Asn 0	-	expression tag
Met 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83314.5
Non-Polymers*	Number of molecules	23
	Total formula weight	1912.7
All*	Total formula weight	85227.2

*Water molecules are not included.