6X2X
Crystal Structure of Mek1NES peptide bound to CRM1(E571K)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GTP-binding nuclear protein Ran | polymer | 216 | 24456.1 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 2 | B | Ran-specific GTPase-activating protein 1 | polymer | 140 | 16320.7 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1 |
| 3 | C | Exportin-1 | polymer | 1024 | 117442.9 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124 |
| 4 | D | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 16 | 1873.1 | 1 | UniProt (Q02750) In PDB | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 5 | A | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | A, C | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
C: 1 - 1058 (UniProt: P30822)
D: 4 - 19 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
| Gly 537 | Asp 537 | conflict |
| Cys 539 | Thr 539 | conflict |
| Glu 540 | Val 540 | conflict |
| Gln 541 | Lys 541 | conflict |
| Lys 582 | Glu 582 | engineered mutation |
| Cys 1022 | Tyr 1022 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | Asn 29 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160092.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 822.8 | |
| All* | Total formula weight | 160915.6 |
