6WXN
EGFR(T790M/V948R) in complex with LN3844
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, B, C | Epidermal growth factor receptor | polymer | 328 | 37479.4 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | D, C | N-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-6-fluoro-3-hydroxybenzamide | non-polymer | 636.7 | 2 | Chemie (UEJ) | |||
3 | B | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | water | water | 18.0 | 244 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 149917.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1839.3 | |
All* | Total formula weight | 151756.7 |