6WXJ
CSF1R signaling is a regulator of pathogenesis in progressive MS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor | polymer | 332 | 37723.1 | 1 | UniProt (P07333) Pfam (PF07714) | Homo sapiens (Human) | CSF-1 receptor,M-CSF-R,Proto-oncogene c-Fms |
| 2 | B (A) | 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine | non-polymer | 455.5 | 1 | Chemie (UF4) | |||
| 3 | C (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 538 - 678 (UniProt: P07333)
A: 753 - 922 (UniProt: P07333)
A: 753 - 922 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Ser 679 | - | linker |
| Pro 733 | - | linker |
| Pro 734 | - | linker |
| Gly 735 | - | linker |
| Leu 736 | - | linker |
| Glu 737 | - | linker |
| Tyr 738 | - | linker |
| Ser 739 | - | linker |
| Tyr 740 | - | linker |
| Asn 741 | - | linker |
| Pro 742 | - | linker |
| Ser 743 | - | linker |
| His 744 | - | linker |
| Asn 745 | - | linker |
| Pro 746 | - | linker |
| Glu 747 | - | linker |
| Glu 748 | - | linker |
| Gln 749 | - | linker |
| Leu 750 | - | linker |
| Ser 751 | - | linker |
| Ser 752 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37723.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 455.5 | |
| All* | Total formula weight | 38178.6 |
