6WX4
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR251
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Non-structural protein 3 | polymer | 326 | 37128.1 | 1 | UniProt (P0DTD1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | papain-like protease,pp1ab,ORF1ab polyprotein,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO |
| 2 | B (I) | VIR251 | polymer | 5 | 479.5 | 1 | BIRD (PRD_002390) | synthetic construct | |
| 3 | C (D) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (D, I) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
D: 0 - 316 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Leu 317 | - | expression tag |
| Glu 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37607.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 37673.1 |
