6WX4
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR251
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | CYS189 |
| D | CYS192 |
| D | CYS224 |
| D | CYS226 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residues ACY A 1 and 73O A 2 |
| Chain | Residue |
| D | ASN156 |
| D | GLY163 |
| D | ASP164 |
| D | PRO248 |
| D | TYR264 |
| D | TYR268 |
| D | TYR273 |
| D | HOH647 |
| I | DPP3 |
| I | HOH101 |
| I | HOH102 |
| D | ASP76 |
| D | ARG82 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residues 73O A 2 and DPP A 3 |
| Chain | Residue |
| I | ACY1 |
| I | GLY4 |
| I | HOH101 |
| D | ASP76 |
| D | ARG82 |
| D | ASN156 |
| D | GLY163 |
| D | ASP164 |
| D | PRO248 |
| D | TYR264 |
| D | TYR268 |
| D | GLN269 |
| D | GLY271 |
| D | TYR273 |
| D | HOH743 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 55 |
| Details | Domain: {"description":"Ubiquitin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32726803","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
