6WVN

Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-Adenosylmethionine.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	2'-O-methyltransferase	polymer	301	33627.5	1	UniProt (P0DTD1) Pfam (PF06460) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	Non-structural protein 16
2	B	Non-structural protein 10	polymer	142	15075.2	1	UniProt (P0DTD1) Pfam (PF09401) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
3	A, B	CHLORIDE ION	non-polymer		35.5	14	Chemie (CL)
4	A	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)
5	A	P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE	non-polymer		787.4	1	Chemie (GTA)
6	A	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE	non-polymer		538.2	1	Chemie (MGP)
7	A	ADENINE	non-polymer		135.1	2	Chemie (ADE)
8	B, A	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
9	B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
10		water	water		18.0	324	Chemie (HOH)

Sequence modifications

A: 6799 - 7096 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 6796	-	expression tag
Asn 6797	-	expression tag
Ala 6798	-	expression tag

B: 4254 - 4392 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 4251	-	expression tag
Asn 4252	-	expression tag
Ala 4253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48702.7
Non-Polymers*	Number of molecules	31
	Total formula weight	3582.1
All*	Total formula weight	52284.8

*Water molecules are not included.