6WRX
Crystal structure of computationally designed protein 2DS25.1 in complex with the human Transferrin receptor ectodomain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transferrin receptor protein 1 | polymer | 640 | 71807.3 | 2 | UniProt (P02786) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | Homo sapiens (Human) | Trfr,T9,p90 |
| 2 | C, D (C, D) | Computationally designed protein 2DS25.1 | polymer | 88 | 10287.8 | 2 | synthetic construct | ||
| 3 | E, F (E, F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H (H) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 6 | I, L (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | J (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | K (B) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A, B: 121 - 760 (UniProt: P02786)
| PDB | External Database | Details |
|---|---|---|
| Ser 142 | Gly 142 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164190.1 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 481.5 | |
| All* | Total formula weight | 167017.8 |
