6WQX

Human PRPK-TPRKB complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, A)	EKC/KEOPS complex subunit TPRKB	polymer	179	20130.5	2	UniProt (Q9Y3C4) Pfam (PF08617)	Homo sapiens (Human)	PRPK-binding protein,TP53RK-binding protein
2	B, D (C, D)	EKC/KEOPS complex subunit TP53RK	polymer	267	29755.1	2	UniProt (Q96S44) Pfam (PF06293)	Homo sapiens (Human)	Atypical serine/threonine protein kinase TP53RK,Nori-2,TP53-regulating kinase,p53-related protein kinase
3	E, H (C, D)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	F, G, I (C, D)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	J, K, L, M (B, C, A, D)	water	water		18.0	65	Chemie (HOH)

Sequence modifications

B, A: 1 - 175 (UniProt: Q9Y3C4)

PDB	External Database	Details
Met -3	-	initiating methionine
Ala -2	-	expression tag
Arg -1	-	expression tag
Ser 0	-	expression tag

C, D: 1 - 253 (UniProt: Q96S44)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	99771.1
Non-Polymers*	Number of molecules	5
	Total formula weight	1085.3
All*	Total formula weight	100856.4

*Water molecules are not included.