6WQX
Human PRPK-TPRKB complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000408 | cellular_component | EKC/KEOPS complex |
| A | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 1990145 | biological_process | maintenance of translational fidelity |
| B | 0000408 | cellular_component | EKC/KEOPS complex |
| B | 0002949 | biological_process | tRNA threonylcarbamoyladenosine modification |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 1990145 | biological_process | maintenance of translational fidelity |
| C | 0000408 | cellular_component | EKC/KEOPS complex |
| C | 0002039 | molecular_function | p53 binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| C | 0106310 | molecular_function | protein serine kinase activity |
| C | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| C | 1990145 | biological_process | maintenance of translational fidelity |
| D | 0000408 | cellular_component | EKC/KEOPS complex |
| D | 0002039 | molecular_function | p53 binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0070525 | biological_process | tRNA threonylcarbamoyladenosine metabolic process |
| D | 0106310 | molecular_function | protein serine kinase activity |
| D | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| D | 1990145 | biological_process | maintenance of translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ANP C 301 |
| Chain | Residue |
| C | LYS40 |
| C | ASN167 |
| C | LEU169 |
| C | ILE182 |
| C | ASP183 |
| C | MG302 |
| C | MG303 |
| C | HOH404 |
| C | HOH408 |
| C | VAL47 |
| C | LYS60 |
| C | PRO99 |
| C | MET113 |
| C | GLU114 |
| C | GLU115 |
| C | ILE116 |
| C | SER166 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | ASN167 |
| C | ASP183 |
| C | ANP301 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 303 |
| Chain | Residue |
| C | ASP183 |
| C | ANP301 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue ANP D 301 |
| Chain | Residue |
| D | LYS40 |
| D | VAL47 |
| D | LYS60 |
| D | PRO99 |
| D | MET113 |
| D | GLU114 |
| D | GLU115 |
| D | ILE116 |
| D | THR121 |
| D | SER166 |
| D | ASN167 |
| D | LEU169 |
| D | ILE182 |
| D | ASP183 |
| D | MG302 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| D | ASN167 |
| D | ASP183 |
| D | ANP301 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LIHgDLTTSNMLL |
| Chain | Residue | Details |
| C | LEU158-LEU170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
