6WPP
HUMAN NIK IN COMPLEX WITH LIGAND COMPOUND X
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase 14 | polymer | 347 | 37961.3 | 2 | UniProt (Q99558) Pfam (PF00069) In PDB | Homo sapiens (Human) | NF-kappa-beta-inducing kinase,HsNIK,Serine/threonine-protein kinase NIK |
| 2 | A, B | 5-fluoro-N-methyl-2-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrimidin-4-amine | non-polymer | 244.2 | 2 | Chemie (PZ4) | |||
| 3 | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B: 343 - 686 (UniProt: Q99558)
| PDB | External Database | Details |
|---|---|---|
| Gly 340 | - | expression tag |
| Pro 341 | - | expression tag |
| Met 342 | - | expression tag |
| Ala 391 | Tyr 391 | conflict |
| Ser 432 | Arg 432 | conflict |
| Ala 464 | Trp 464 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75922.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 488.5 | |
| All* | Total formula weight | 76411.1 |
