6WO8

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5-diphosphoinositol 1,3,4,6-tetrakisphosphate (5-PP-IP4), Mg, and Fluoride ion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Diphosphoinositol polyphosphate phosphohydrolase 1	polymer	169	19542.9	1	UniProt (O95989) Pfam (PF00293) In PDB	Homo sapiens (Human)	DIPP-1,Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1,Nucleoside diphosphate-linked moiety X motif 3,Nudix motif 3
2	A	(1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate	non-polymer		660.0	1	Chemie (U6J)
3	A	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	A	FLUORIDE ION	non-polymer		19.0	1	Chemie (F)
7		water	water		18.0	159	Chemie (HOH)

Sequence modifications

A: 1 - 148 (UniProt: O95989)

PDB	External Database	Details
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19542.9
Non-Polymers*	Number of molecules	7
	Total formula weight	883.5
All*	Total formula weight	20426.4

*Water molecules are not included.