6WMZ

Crystal structure of human SFPQ/NONO complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Splicing factor, proline- and glutamine-rich	polymer	388	44759.4	2	UniProt (P23246) Pfam (PF00076) Pfam (PF08075) In PDB	Homo sapiens (Human)	100 kDa DNA-pairing protein,hPOMp100,DNA-binding p52/p100 complex,100 kDa subunit,Polypyrimidine tract-binding protein-associated-splicing factor,PTB-associated-splicing factor
2	B, D	Non-POU domain-containing octamer-binding protein	polymer	261	30278.7	2	UniProt (Q15233) Pfam (PF00076) Pfam (PF08075) In PDB	Homo sapiens (Human)	NonO protein,54 kDa nuclear RNA- and DNA-binding protein,55 kDa nuclear protein,DNA-binding p52/p100 complex,52 kDa subunit,NMT55,p54(nrb),p54nrb
3	D	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4		water	water		18.0	39	Chemie (HOH)

Sequence modifications

A, C: 214 - 598 (UniProt: P23246)

PDB	External Database	Details
Gly 211	-	expression tag
Ala 212	-	expression tag
Met 213	-	expression tag

B, D: 53 - 312 (UniProt: Q15233)

PDB	External Database	Details
Met 52	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	150076.2
Non-Polymers*	Number of molecules	1
	Total formula weight	96.1
All*	Total formula weight	150172.3

*Water molecules are not included.