6WMH

Next generation monomeric IgG4 Fc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (H, A)	Immunoglobulin heavy constant gamma 4	polymer	207	23789.7	2	UniProt (P01861) Pfam (PF07654)	Homo sapiens (Human)	Ig gamma-4 chain C region
2	C, D (H, A)	water	water		18.0	154	Chemie (HOH)

Sequence modifications

H, A: 238 - 444 (UniProt: P01861)

PDB	External Database	Details
Tyr 252	Met 132	engineered mutation
Thr 254	Ser 134	engineered mutation
Glu 256	Thr 136	engineered mutation
Asp 297	Asn 177	engineered mutation
Phe 351	Leu 231	engineered mutation
Glu 354	Ser 234	engineered mutation
Arg 366	Thr 246	engineered mutation
Lys 395	Pro 275	engineered mutation
Arg 405	Phe 285	engineered mutation
Glu 407	Tyr 287	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47579.3
All*	Total formula weight	47579.3

*Water molecules are not included.