6WM2
Human V-ATPase in state 1 with SidK and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H, I, J | V-type proton ATPase subunit E 1 | polymer | 226 | 26183.3 | 3 | UniProt (P36543) Pfam (PF01991) In PDB | Homo sapiens (Human) | V-ATPase subunit E 1,V-ATPase 31 kDa subunit,p31,Vacuolar proton pump subunit E 1 |
| 2 | K, L, M | V-type proton ATPase subunit G 1 | polymer | 118 | 13781.5 | 3 | UniProt (O75348) Pfam (PF03179) In PDB | Homo sapiens (Human) | V-ATPase subunit G 1,V-ATPase 13 kDa subunit 1,Vacuolar proton pump subunit G 1,Vacuolar proton pump subunit M16 |
| 3 | O | V-type proton ATPase subunit C 1 | polymer | 382 | 43999.5 | 1 | UniProt (P21283) Pfam (PF03223) In PDB | Homo sapiens (Human) | V-ATPase subunit C 1,Vacuolar proton pump subunit C 1 |
| 4 | P | V-type proton ATPase subunit H | polymer | 483 | 55949.9 | 1 | UniProt (Q9UI12) Pfam (PF03224) Pfam (PF11698) In PDB | Homo sapiens (Human) | V-ATPase subunit H,Nef-binding protein 1,NBP1,Protein VMA13 homolog,V-ATPase 50/57 kDa subunits,Vacuolar proton pump subunit H,Vacuolar proton pump subunit SFD |
| 5 | R | V-type proton ATPase 116 kDa subunit a isoform 1 | polymer | 837 | 96512.4 | 1 | UniProt (Q93050) Pfam (PF01496) In PDB | Homo sapiens (Human) | V-ATPase 116 kDa isoform a1,Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit,Vacuolar adenosine triphosphatase subunit Ac116,Vacuolar proton pump subunit 1,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
| 6 | A, B, C | V-type proton ATPase catalytic subunit A | polymer | 617 | 68379.9 | 3 | UniProt (P38606) Pfam (PF02874) Pfam (PF16886) Pfam (PF00006) Pfam (PF22919) In PDB | Homo sapiens (Human) | V-ATPase subunit A,V-ATPase 69 kDa subunit,Vacuolar ATPase isoform VA68,Vacuolar proton pump subunit alpha |
| 7 | D, E, F | V-type proton ATPase subunit B, brain isoform | polymer | 511 | 56561.5 | 3 | UniProt (P21281) Pfam (PF00006) Pfam (PF22919) Pfam (PF02874) In PDB | Homo sapiens (Human) | V-ATPase subunit B 2,Endomembrane proton pump 58 kDa subunit,HO57,Vacuolar proton pump subunit B 2 |
| 8 | X, Y, Z | SidK | polymer | 573 | 65505.3 | 3 | UniProt (A0A4T1L9X6) UniProt (by SIFTS) (Q5ZWW6) In PDB | Legionella pneumophila | |
| 9 | G | V-type proton ATPase subunit D | polymer | 247 | 28311.9 | 1 | UniProt (Q9Y5K8) Pfam (PF01813) In PDB | Homo sapiens (Human) | V-ATPase subunit D,V-ATPase 28 kDa accessory protein,Vacuolar proton pump subunit D |
| 10 | N | V-type proton ATPase subunit F | polymer | 119 | 13388.2 | 1 | UniProt (Q16864) Pfam (PF01990) In PDB | Homo sapiens (Human) | V-ATPase subunit F,V-ATPase 14 kDa subunit,Vacuolar proton pump subunit F |
| 11 | 0 | V-type proton ATPase 21 kDa proteolipid subunit | polymer | 205 | 21418.2 | 1 | UniProt (Q99437) Pfam (PF00137) In PDB | Homo sapiens (Human) | V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit,hATPL |
| 12 | 1, 2, 3, 4, 5... | V-type proton ATPase 16 kDa proteolipid subunit | polymer | 155 | 15743.7 | 9 | UniProt (P27449) Pfam (PF00137) In PDB | Homo sapiens (Human) | V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit |
| 13 | Q | V-type proton ATPase subunit d 1 | polymer | 351 | 40369.9 | 1 | UniProt (P61421) Pfam (PF01992) In PDB | Homo sapiens (Human) | V-ATPase subunit d 1,32 kDa accessory protein,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,p39,Vacuolar proton pump subunit d 1 |
| 14 | S | V-type proton ATPase subunit e 1 | polymer | 81 | 9380.3 | 1 | UniProt (O15342) Pfam (PF05493) In PDB | Homo sapiens (Human) | V-ATPase subunit e 1,V-ATPase 9.2 kDa membrane accessory protein,V-ATPase M9.2 subunit,Vacuolar proton pump subunit e 1 |
| 15 | T | Ribonuclease kappa | polymer | 137 | 15435.2 | 1 | UniProt (Q6P5S7) In PDB | Homo sapiens (Human) | RNase kappa |
| 16 | U | V-type proton ATPase subunit S1 | polymer | 470 | 52067.5 | 1 | UniProt (Q15904) Pfam (PF05827) Pfam (PF20520) In PDB | Homo sapiens (Human) | V-ATPase subunit S1,Protein XAP-3,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1 |
| 17 | V | Renin receptor | polymer | 350 | 39045.9 | 1 | UniProt (O75787) Pfam (PF07850) In PDB | Homo sapiens (Human) | ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,ER-localized type I transmembrane adapter,Embryonic liver differentiation factor 10,N14F,Renin/prorenin receptor,Vacuolar ATP synthase membrane sector-associated protein M8-9,V-ATPase M8.9 subunit |
| 18 | W | beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 998.9 | 1 | In PDB GlyTouCan (G48558GR) | |||
| 19 | a | beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose | branched | 836.7 | 1 | In PDB GlyTouCan (G50886AE) | |||
| 20 | u, b, c, d, s | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 21 | r | alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB GlyTouCan (G71069MN) | |||
| 22 | 0, 5, R, V | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 23 | R | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE | non-polymer | 455.4 | 1 | Chemie (PSF) | |||
| 24 | 0, 2, 5, 6, 7... | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 13 | Chemie (PTY) | |||
| 25 | 0, 1, 3, U, R... | tri(methyl)-[2-[[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[(~{E})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium | non-polymer | 787.1 | 10 | Chemie (WSS) | |||
| 26 | U, R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 27 | R | methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate | non-polymer | 534.6 | 1 | Chemie (WJP) | |||
| 28 | C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 29 | 3 | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid | non-polymer | 497.4 | 1 | Chemie (WJS) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 35 |
| Total formula weight | 1248806.6 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 5841.3 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 21317.4 | |
| All* | Total formula weight | 1275965.3 |
