6WK2
SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (Y, C) | Actin, cytoplasmic 2 | polymer | 23 | 2861.3 | 2 | UniProt (P63261) | Homo sapiens | Gamma-actin |
| 2 | B, D (A, D) | Actin-histidine N-methyltransferase | polymer | 594 | 67327.1 | 2 | UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273) | Homo sapiens (Human) | SET domain-containing protein 3,hSETD3 |
| 3 | E, M (A, D) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | F, G, H, I, J... (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | O (D) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | P, Q, R, S (Y, A, C, D) | water | water | 18.0 | 731 | Chemie (HOH) |
Sequence modifications
Y, C: 66 - 88 (UniProt: P63261)
A, D: 0 - 593 (UniProt: Q86TU7)
| PDB | External Database | Details |
|---|---|---|
| Met 73 | His 73 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val 255 | Asn 256 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 140376.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1316.4 | |
| All* | Total formula weight | 141693.2 |
