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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WK2

SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0003713molecular_functiontranscription coactivator activity
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0006338biological_processchromatin remodeling
A0008168molecular_functionmethyltransferase activity
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0016740molecular_functiontransferase activity
A0018021biological_processpeptidyl-histidine methylation
A0018023biological_processpeptidyl-lysine trimethylation
A0018064molecular_functionprotein-L-histidine N-tele-methyltransferase activity
A0030047biological_processactin modification
A0032259biological_processmethylation
A0042800molecular_functionhistone H3K4 methyltransferase activity
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046975molecular_functionhistone H3K36 methyltransferase activity
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070472biological_processregulation of uterine smooth muscle contraction
D0000785cellular_componentchromatin
D0003713molecular_functiontranscription coactivator activity
D0003779molecular_functionactin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0006338biological_processchromatin remodeling
D0008168molecular_functionmethyltransferase activity
D0016279molecular_functionprotein-lysine N-methyltransferase activity
D0016740molecular_functiontransferase activity
D0018021biological_processpeptidyl-histidine methylation
D0018023biological_processpeptidyl-lysine trimethylation
D0018064molecular_functionprotein-L-histidine N-tele-methyltransferase activity
D0030047biological_processactin modification
D0032259biological_processmethylation
D0042800molecular_functionhistone H3K4 methyltransferase activity
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046975molecular_functionhistone H3K36 methyltransferase activity
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070472biological_processregulation of uterine smooth muscle contraction
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue SAM A 601
ChainResidue
AARG74
ACYS276
AASN277
AHIS278
ATYR312
ASER324
APHE326
AHOH760
AHOH810
AHOH874
AHOH925
AGLU102
AHOH944
AHOH959
YMET73
AGLU103
APHE105
APRO179
ATHR252
AARG253
AASP274
AMET275
site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 602
ChainResidue
ALYS101
AGLU102
AHOH722
DLYS101
site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 603
ChainResidue
AILE24
AGLN63
ATYR220
ASER237
APHE238
site_idAC4
Number of Residues7
Detailsbinding site for residue EDO A 604
ChainResidue
ALEU399
AGLY400
AASP401
ASER402
AALA403
AARG406
AHOH704
site_idAC5
Number of Residues2
Detailsbinding site for residue EDO A 605
ChainResidue
AGLU102
DLYS101
site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 606
ChainResidue
AASP334
APHE371
AGLY469
AGLU472
AILE473
AHOH713
site_idAC7
Number of Residues4
Detailsbinding site for residue EDO A 607
ChainResidue
ALEU340
AGLY341
AARG432
AHOH922
site_idAC8
Number of Residues3
Detailsbinding site for residue EDO A 608
ChainResidue
AGLU96
AMET97
AHOH935
site_idAC9
Number of Residues21
Detailsbinding site for residue SAM D 601
ChainResidue
CMET73
DARG74
DGLU102
DGLU103
DPHE105
DPRO179
DTHR252
DARG253
DASP274
DMET275
DCYS276
DASN277
DHIS278
DTYR312
DSER324
DPHE326
DHOH741
DHOH820
DHOH822
DHOH890
DHOH929
site_idAD1
Number of Residues5
Detailsbinding site for residue EDO D 602
ChainResidue
DLEU340
DGLY341
DPHE387
DARG432
DHOH868
site_idAD2
Number of Residues1
Detailsbinding site for residue NA D 603
ChainResidue
DSER198
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W.","Dozynkiewicz M.","Norman J.C."]}}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues440
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

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