6WJJ

Anthrax octamer prechannel bound to full-length lethal factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, C, D, E)	Protective antigen	polymer	735	82511.3	4	UniProt (P13423) Pfam (PF07691) Pfam (PF03495) Pfam (PF17475) Pfam (PF17476) Pfam (PF20835)	Bacillus anthracis	PA,Anthrax toxins translocating protein,PA-83,PA83
2	B, E, H, K (B, F, G, H)	Protective antigen	polymer	735	82639.7	4	UniProt (P13423) Pfam (PF20835) Pfam (PF07691) Pfam (PF03495) Pfam (PF17475) Pfam (PF17476)	Bacillus anthracis	PA,Anthrax toxins translocating protein,PA-83,PA83
3	C, F, I, L (L, I, J, K)	Lethal factor	polymer	776	90356.8	4	UniProt (I3XID8) Pfam (PF07737) Pfam (PF09156) UniProt (by SIFTS) (P15917)	Bacillus anthracis
4	AA, BA, EA, FA, GA... (G, E, H, A, B...)	CALCIUM ION	non-polymer		40.1	16	Chemie (CA)
5	CA, IA, Q, W (J, K, L, I)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6	DA, JA, R, X (J, K, L, I)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, C, D, E: 1 - 735 (UniProt: P13423)

PDB	External Database	Details
Asp 121	Asn 153	conflict
Leu 161	Arg 193	conflict
Glu 162	Lys 194	conflict
Val 163	-	insertion
Leu 164	-	insertion
Phe 165	-	insertion
Gln 166	Lys 195	conflict
Gly 167	Arg 196	conflict
Gly 245	Lys 274	engineered mutation
Asn 252	Arg 281	engineered mutation

B, F, G, H: 1 - 735 (UniProt: P13423)

PDB	External Database	Details
Leu 161	Arg 193	conflict
Glu 162	Lys 194	conflict
Val 163	-	insertion
Leu 164	-	insertion
Phe 165	-	insertion
Gln 166	Lys 195	conflict
Gly 167	Arg 196	conflict
Lys 512	Asp 541	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1022031.3
Non-Polymers*	Number of molecules	24
	Total formula weight	1287.1
All*	Total formula weight	1023318.4

*Water molecules are not included.