Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WJJ

Anthrax octamer prechannel bound to full-length lethal factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0005576	cellular_component	extracellular region
C	0051260	biological_process	protein homooligomerization
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0005576	cellular_component	extracellular region
F	0051260	biological_process	protein homooligomerization
G	0005576	cellular_component	extracellular region
G	0051260	biological_process	protein homooligomerization
H	0005576	cellular_component	extracellular region
H	0051260	biological_process	protein homooligomerization
I	0003824	molecular_function	catalytic activity
I	0004222	molecular_function	metalloendopeptidase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0016787	molecular_function	hydrolase activity
I	0035821	biological_process	modulation of process of another organism
I	0044164	cellular_component	host cell cytosol
I	0046872	molecular_function	metal ion binding
I	0090729	molecular_function	toxin activity
J	0003824	molecular_function	catalytic activity
J	0004222	molecular_function	metalloendopeptidase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0006508	biological_process	proteolysis
J	0008233	molecular_function	peptidase activity
J	0008237	molecular_function	metallopeptidase activity
J	0008270	molecular_function	zinc ion binding
J	0016787	molecular_function	hydrolase activity
J	0035821	biological_process	modulation of process of another organism
J	0044164	cellular_component	host cell cytosol
J	0046872	molecular_function	metal ion binding
J	0090729	molecular_function	toxin activity
K	0003824	molecular_function	catalytic activity
K	0004222	molecular_function	metalloendopeptidase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0016787	molecular_function	hydrolase activity
K	0035821	biological_process	modulation of process of another organism
K	0044164	cellular_component	host cell cytosol
K	0046872	molecular_function	metal ion binding
K	0090729	molecular_function	toxin activity
L	0003824	molecular_function	catalytic activity
L	0004222	molecular_function	metalloendopeptidase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0008233	molecular_function	peptidase activity
L	0008237	molecular_function	metallopeptidase activity
L	0008270	molecular_function	zinc ion binding
L	0016787	molecular_function	hydrolase activity
L	0035821	biological_process	modulation of process of another organism
L	0044164	cellular_component	host cell cytosol
L	0046872	molecular_function	metal ion binding
L	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 801

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188
A	CA802

site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 802

Chain	Residue
A	SER222
A	LYS225
A	ASP235
A	CA801
A	ASP179
A	ASP181
A	GLU188

site_id	AC3
Number of Residues	6
Details	binding site for residue CA B 801

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188
B	CA802

site_id	AC4
Number of Residues	8
Details	binding site for residue CA B 802

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER221
B	SER222
B	LYS225
B	ASP235
B	CA801

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 L 801

Chain	Residue
L	ARG267
L	TYR268

site_id	AC6
Number of Residues	1
Details	binding site for residue ZN L 802

Chain	Residue
L	TYR728

site_id	AC7
Number of Residues	6
Details	binding site for residue CA C 801

Chain	Residue
C	ASP177
C	ASP179
C	ASP181
C	ILE183
C	GLU188
C	CA802

site_id	AC8
Number of Residues	7
Details	binding site for residue CA C 802

Chain	Residue
C	ASP179
C	ASP181
C	GLU188
C	SER222
C	LYS225
C	ASP235
C	CA801

site_id	AC9
Number of Residues	6
Details	binding site for residue CA F 801

Chain	Residue
F	ASP177
F	ASP179
F	ASP181
F	ILE183
F	GLU188
F	CA802

site_id	AD1
Number of Residues	8
Details	binding site for residue CA F 802

Chain	Residue
F	ASP179
F	ASP181
F	GLU188
F	SER221
F	SER222
F	LYS225
F	ASP235
F	CA801

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 I 801

Chain	Residue
I	ARG267
I	TYR268

site_id	AD3
Number of Residues	1
Details	binding site for residue ZN I 802

Chain	Residue
I	TYR728

site_id	AD4
Number of Residues	6
Details	binding site for residue CA D 801

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	GLU188
D	CA802

site_id	AD5
Number of Residues	7
Details	binding site for residue CA D 802

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235
D	CA801

site_id	AD6
Number of Residues	6
Details	binding site for residue CA G 801

Chain	Residue
G	ASP177
G	ASP179
G	ASP181
G	ILE183
G	GLU188
G	CA802

site_id	AD7
Number of Residues	8
Details	binding site for residue CA G 802

Chain	Residue
G	ASP179
G	ASP181
G	GLU188
G	SER221
G	SER222
G	LYS225
G	ASP235
G	CA801

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 J 801

Chain	Residue
J	ARG267
J	TYR268

site_id	AD9
Number of Residues	1
Details	binding site for residue ZN J 802

Chain	Residue
J	TYR728

site_id	AE1
Number of Residues	6
Details	binding site for residue CA E 801

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	GLU188
E	CA802

site_id	AE2
Number of Residues	7
Details	binding site for residue CA E 802

Chain	Residue
E	SER222
E	LYS225
E	ASP235
E	CA801
E	ASP179
E	ASP181
E	GLU188

site_id	AE3
Number of Residues	6
Details	binding site for residue CA H 801

Chain	Residue
H	ASP177
H	ASP179
H	ASP181
H	ILE183
H	GLU188
H	CA802

site_id	AE4
Number of Residues	8
Details	binding site for residue CA H 802

Chain	Residue
H	ASP179
H	ASP181
H	GLU188
H	SER221
H	SER222
H	LYS225
H	ASP235
H	CA801

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 K 801

Chain	Residue
K	ARG267
K	TYR268

site_id	AE6
Number of Residues	1
Details	binding site for residue ZN K 802

Chain	Residue
K	TYR728

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV

Chain	Residue	Details
L	GLY683-VAL692

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	856
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1112
Details	Region: {"description":"Domain 4, binding to the receptor","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	32
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Site: {"description":"Phi-clamp","evidences":[{"source":"PubMed","id":"16051798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	848
Details	Domain: {"description":"ATLF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	780
Details	Domain: {"description":"ATLF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	72
Details	Repeat: {"description":"1","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	60
Details	Repeat: {"description":"2","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	72
Details	Repeat: {"description":"3","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	136
Details	Region: {"description":"IIA","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	652
Details	Region: {"description":"IIB","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19651869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9573135","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718924","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718925","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15911756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22342144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25372673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26492514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26578066","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J7N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DV8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 641

Chain	Residue	Details
C	PRO686	metal ligand
C	LEU687	proton acceptor, proton donor
C	SER690	metal ligand
C	SER728	electrostatic stabiliser
C	GLY735	metal ligand

site_id	MCSA2
Number of Residues	5
Details	M-CSA 641

Chain	Residue	Details
F	PRO686	metal ligand
F	LEU687	proton acceptor, proton donor
F	SER690	metal ligand
F	SER728	electrostatic stabiliser
F	GLY735	metal ligand

site_id	MCSA3
Number of Residues	5
Details	M-CSA 641

Chain	Residue	Details
I	HIS686	metal ligand
I	GLU687	proton acceptor, proton donor
I	HIS690	metal ligand
I	TYR728	electrostatic stabiliser
I	GLU735	metal ligand

site_id	MCSA4
Number of Residues	5
Details	M-CSA 641

Chain	Residue	Details
L	HIS686	metal ligand
L	GLU687	proton acceptor, proton donor
L	HIS690	metal ligand
L	TYR728	electrostatic stabiliser
L	GLU735	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)