6WFO
Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4b) identified using DNA encoded library technology
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | N-alpha-acetyltransferase 50 | polymer | 171 | 19571.5 | 3 | UniProt (Q9GZZ1) Pfam (PF00583) | Homo sapiens (Human) | hNaa50p,N-acetyltransferase 13,N-acetyltransferase 5,hNAT5,N-acetyltransferase san homolog,hSAN,N-epsilon-acetyltransferase 50,NatE catalytic subunit, Naa50 |
| 2 | D, F, H (A, B, C) | ACETYL COENZYME *A | non-polymer | 809.6 | 3 | Chemie (ACO) PubChem (25210474) PubChem (444493) PubChem (24860528) PubChem (44141873) PubChem (45254004) PubChem (53393727) PubChem (56846401) PubChem (53245716) PubChem (181) PubChem (6302) PubChem (87656764) PubChem (6917106) PubChem (91746285) PubChem (10079099) PubChem (87656765) PubChem (89102998) PubChem (11987898) PubChem (16061174) PubChem (6857822) PubChem (134956084) PubChem (124511019) PubChem (124931617) PubChem (129274027) PubChem (154496096) PubChem (162968672) PubChem (170108977) | |||
| 3 | E, G, I (A, B, C) | (4S)-1-methyl-N-{(3S,5R)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide | non-polymer | 552.6 | 3 | Chemie (U3Y) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 169 (UniProt: Q9GZZ1)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58714.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 4086.4 | |
| All* | Total formula weight | 62800.9 |
