6WFO
Crystal structure of human Naa50 in complex with AcCoA and an inhibitor (compound 4b) identified using DNA encoded library technology
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | N-alpha-acetyltransferase 50 | polymer | 171 | 19571.5 | 3 | UniProt (Q9GZZ1) Pfam (PF00583) | Homo sapiens (Human) | hNaa50p,N-acetyltransferase 13,N-acetyltransferase 5,hNAT5,N-acetyltransferase san homolog,hSAN,N-epsilon-acetyltransferase 50,NatE catalytic subunit, Naa50 |
| 2 | D, F, H (A, B, C) | ACETYL COENZYME *A | non-polymer | 809.6 | 3 | Chemie (ACO) | |||
| 3 | E, G, I (A, B, C) | (4S)-1-methyl-N-{(3S,5R)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide | non-polymer | 552.6 | 3 | Chemie (U3Y) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 169 (UniProt: Q9GZZ1)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58714.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 4086.4 | |
| All* | Total formula weight | 62800.9 |
