6WEO
IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 0, 3, 6, 9, C... | Interleukin-10 receptor subunit beta | polymer | 204 | 23808.4 | 12 | UniProt (Q61190) Pfam (PF01108) Pfam (PF09294) In PDB | Mus musculus (Mouse) | IL-10RB,Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,CRF2-4,Interleukin-10 receptor subunit 2,IL-10R2 |
| 2 | 1, 4, 7, A, B... | Interleukin-22 receptor subunit alpha-1 | polymer | 204 | 23256.5 | 12 | UniProt (Q80XZ4) Pfam (PF01108) In PDB | Mus musculus (Mouse) | IL-22RA1 |
| 3 | 2, 5, 8, D, G... | Interleukin-22 | polymer | 149 | 16986.7 | 12 | UniProt (Q9JJY9) Pfam (PF14565) In PDB | Mus musculus (Mouse) | IL-22,IL-10-related T-cell-derived-inducible factor,IL-TIF,IL-TIF alpha,Interleukin-22a,IL-22a |
| 4 | a, c, n | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 3 | In PDB GlyTouCan (G32152BH) | |||
| 5 | s, b, e, i, j... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 7 | In PDB GlyTouCan (G21290RB) | |||
| 6 | r, t, u, v, d... | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 7 | In PDB GlyTouCan (G86851RC) | |||
| 7 | f | alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G80587NA) | |||
| 8 | g | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | h, k | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 878.8 | 2 | In PDB GlyTouCan (G92953ND) | |||
| 10 | q | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 11 | w | alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 513.5 | 1 | In PDB GlyTouCan (G04836KE) | |||
| 12 | A, H, J, K, M... | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 13 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 14 | water | water | 18.0 | 340 | Chemie (HOH) |
Sequence modifications
0, 3, 6, 9, C, E, H, K, O, R, U, X: 20 - 220 (UniProt: Q61190)
1, 4, 7, A, B, F, I, M, P, S, V, Y: 24 - 224 (UniProt: Q80XZ4)
2, 5, 8, D, G, J, L, N, Q, T, W, Z: 34 - 179 (UniProt: Q9JJY9)
| PDB | External Database | Details |
|---|---|---|
| Gln 49 | Asn 49 | conflict |
| Gln 102 | Asn 102 | conflict |
| Gln 161 | Asn 161 | conflict |
| Gln 199 | Asn 199 | conflict |
| Gly 221 | - | expression tag |
| Gly 222 | - | expression tag |
| Ser 223 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 80 | Asn 80 | conflict |
| Asp 87 | Asn 87 | conflict |
| Gln 89 | Thr 89 | conflict |
| Gly 225 | - | expression tag |
| Gly 226 | - | expression tag |
| Ser 227 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 43 | Glu 43 | conflict |
| Arg 45 | Ser 45 | conflict |
| Ser 49 | Gln 49 | conflict |
| Gln 68 | Asn 68 | conflict |
| Gln 97 | Asn 97 | conflict |
| Trp 116 | Gln 116 | conflict |
| Lys 128 | Gln 128 | conflict |
| Gly 180 | - | expression tag |
| Gly 181 | - | expression tag |
| Ser 182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 36 |
| Total formula weight | 768619.5 | |
| Branched | Number of molecules | 23 |
| Total formula weight | 12412.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 865.9 | |
| All* | Total formula weight | 781898.1 |
