Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WEO

IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0005125	molecular_function	cytokine activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0007165	biological_process	signal transduction
2	0045944	biological_process	positive regulation of transcription by RNA polymerase II
2	0050728	biological_process	negative regulation of inflammatory response
2	0072593	biological_process	reactive oxygen species metabolic process
5	0005125	molecular_function	cytokine activity
5	0005515	molecular_function	protein binding
5	0005576	cellular_component	extracellular region
5	0005615	cellular_component	extracellular space
5	0007165	biological_process	signal transduction
5	0045944	biological_process	positive regulation of transcription by RNA polymerase II
5	0050728	biological_process	negative regulation of inflammatory response
5	0072593	biological_process	reactive oxygen species metabolic process
8	0005125	molecular_function	cytokine activity
8	0005515	molecular_function	protein binding
8	0005576	cellular_component	extracellular region
8	0005615	cellular_component	extracellular space
8	0007165	biological_process	signal transduction
8	0045944	biological_process	positive regulation of transcription by RNA polymerase II
8	0050728	biological_process	negative regulation of inflammatory response
8	0072593	biological_process	reactive oxygen species metabolic process
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007165	biological_process	signal transduction
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0050728	biological_process	negative regulation of inflammatory response
D	0072593	biological_process	reactive oxygen species metabolic process
G	0005125	molecular_function	cytokine activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0007165	biological_process	signal transduction
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0050728	biological_process	negative regulation of inflammatory response
G	0072593	biological_process	reactive oxygen species metabolic process
J	0005125	molecular_function	cytokine activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0007165	biological_process	signal transduction
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0050728	biological_process	negative regulation of inflammatory response
J	0072593	biological_process	reactive oxygen species metabolic process
L	0005125	molecular_function	cytokine activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0007165	biological_process	signal transduction
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0050728	biological_process	negative regulation of inflammatory response
L	0072593	biological_process	reactive oxygen species metabolic process
N	0005125	molecular_function	cytokine activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0007165	biological_process	signal transduction
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0050728	biological_process	negative regulation of inflammatory response
N	0072593	biological_process	reactive oxygen species metabolic process
Q	0005125	molecular_function	cytokine activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0007165	biological_process	signal transduction
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0050728	biological_process	negative regulation of inflammatory response
Q	0072593	biological_process	reactive oxygen species metabolic process
T	0005125	molecular_function	cytokine activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0007165	biological_process	signal transduction
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0050728	biological_process	negative regulation of inflammatory response
T	0072593	biological_process	reactive oxygen species metabolic process
W	0005125	molecular_function	cytokine activity
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005615	cellular_component	extracellular space
W	0007165	biological_process	signal transduction
W	0045944	biological_process	positive regulation of transcription by RNA polymerase II
W	0050728	biological_process	negative regulation of inflammatory response
W	0072593	biological_process	reactive oxygen species metabolic process
Z	0005125	molecular_function	cytokine activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0007165	biological_process	signal transduction
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0050728	biological_process	negative regulation of inflammatory response
Z	0072593	biological_process	reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00520
Number of Residues	21
Details	INTERLEUKIN_10 Interleukin-10 family signature. SakdqCYlmkqVLqFTLeDVL

Chain	Residue	Details
Q	SER84-LEU104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
2	ASN54
D	ASN54
D	GLN68
D	GLN97
G	ASN54
G	GLN68
G	GLN97
J	ASN54
J	GLN68
J	GLN97
L	ASN54
2	GLN68
L	GLN68
L	GLN97
N	ASN54
N	GLN68
N	GLN97
Q	ASN54
Q	GLN68
Q	GLN97
T	ASN54
T	GLN68
2	GLN97
T	GLN97
W	ASN54
W	GLN68
W	GLN97
Z	ASN54
Z	GLN68
Z	GLN97
5	ASN54
5	GLN68
5	GLN97
8	ASN54
8	GLN68
8	GLN97

site_id	SWS_FT_FI2
Number of Residues	48
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
0	GLN49
6	GLN102
6	GLN161
6	GLN199
9	GLN49
9	GLN102
9	GLN161
9	GLN199
C	GLN49
C	GLN102
C	GLN161
0	GLN102
C	GLN199
E	GLN49
E	GLN102
E	GLN161
E	GLN199
H	GLN49
H	GLN102
H	GLN161
H	GLN199
K	GLN49
0	GLN161
K	GLN102
K	GLN161
K	GLN199
O	GLN49
O	GLN102
O	GLN161
O	GLN199
R	GLN49
R	GLN102
R	GLN161
0	GLN199
R	GLN199
U	GLN49
U	GLN102
U	GLN161
U	GLN199
X	GLN49
X	GLN102
X	GLN161
X	GLN199
3	GLN49
3	GLN102
3	GLN161
3	GLN199
6	GLN49

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)