6WEO

IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0005125	molecular_function	cytokine activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0007165	biological_process	signal transduction
2	0045944	biological_process	positive regulation of transcription by RNA polymerase II
2	0050728	biological_process	negative regulation of inflammatory response
2	0072593	biological_process	reactive oxygen species metabolic process
2	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
5	0005125	molecular_function	cytokine activity
5	0005515	molecular_function	protein binding
5	0005576	cellular_component	extracellular region
5	0005615	cellular_component	extracellular space
5	0007165	biological_process	signal transduction
5	0045944	biological_process	positive regulation of transcription by RNA polymerase II
5	0050728	biological_process	negative regulation of inflammatory response
5	0072593	biological_process	reactive oxygen species metabolic process
5	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
8	0005125	molecular_function	cytokine activity
8	0005515	molecular_function	protein binding
8	0005576	cellular_component	extracellular region
8	0005615	cellular_component	extracellular space
8	0007165	biological_process	signal transduction
8	0045944	biological_process	positive regulation of transcription by RNA polymerase II
8	0050728	biological_process	negative regulation of inflammatory response
8	0072593	biological_process	reactive oxygen species metabolic process
8	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007165	biological_process	signal transduction
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0050728	biological_process	negative regulation of inflammatory response
D	0072593	biological_process	reactive oxygen species metabolic process
D	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
G	0005125	molecular_function	cytokine activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0007165	biological_process	signal transduction
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0050728	biological_process	negative regulation of inflammatory response
G	0072593	biological_process	reactive oxygen species metabolic process
G	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
J	0005125	molecular_function	cytokine activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0007165	biological_process	signal transduction
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0050728	biological_process	negative regulation of inflammatory response
J	0072593	biological_process	reactive oxygen species metabolic process
J	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
L	0005125	molecular_function	cytokine activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0007165	biological_process	signal transduction
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0050728	biological_process	negative regulation of inflammatory response
L	0072593	biological_process	reactive oxygen species metabolic process
L	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
N	0005125	molecular_function	cytokine activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0007165	biological_process	signal transduction
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0050728	biological_process	negative regulation of inflammatory response
N	0072593	biological_process	reactive oxygen species metabolic process
N	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
Q	0005125	molecular_function	cytokine activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0007165	biological_process	signal transduction
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0050728	biological_process	negative regulation of inflammatory response
Q	0072593	biological_process	reactive oxygen species metabolic process
Q	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
T	0005125	molecular_function	cytokine activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0007165	biological_process	signal transduction
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0050728	biological_process	negative regulation of inflammatory response
T	0072593	biological_process	reactive oxygen species metabolic process
T	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
W	0005125	molecular_function	cytokine activity
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005615	cellular_component	extracellular space
W	0007165	biological_process	signal transduction
W	0045944	biological_process	positive regulation of transcription by RNA polymerase II
W	0050728	biological_process	negative regulation of inflammatory response
W	0072593	biological_process	reactive oxygen species metabolic process
W	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
Z	0005125	molecular_function	cytokine activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0007165	biological_process	signal transduction
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0050728	biological_process	negative regulation of inflammatory response
Z	0072593	biological_process	reactive oxygen species metabolic process
Z	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response

Functional Information from PROSITE/UniProt

site_id	PS00520
Number of Residues	21
Details	INTERLEUKIN_10 Interleukin-10 family signature. SakdqCYlmkqVLqFTLeDVL

Chain	Residue	Details
Q	SER84-LEU104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1056
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	107
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	206
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	960
Details	Domain: {"description":"Fibronectin type-III 2"}

Chain

Residue

Details

---