6WE4
Human PARP14 (ARTD8), catalytic fragment in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein mono-ADP-ribosyltransferase PARP14 | polymer | 194 | 22172.6 | 2 | UniProt (Q460N5) Pfam (PF00644) | Homo sapiens (Human) | ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2,Poly [ADP-ribose] polymerase 14,PARP-14 |
| 2 | C (A) | 2-methyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one | non-polymer | 206.3 | 1 | Chemie (FDR) | |||
| 3 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | J (B) | 8-methyl-2-{[(pyridin-4-yl)sulfanyl]methyl}quinazolin-4(3H)-one | non-polymer | 283.3 | 1 | Chemie (TYG) | |||
| 5 | K, L (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B: 1611 - 1801 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Ser 1608 | - | expression tag |
| Asn 1609 | - | expression tag |
| Ala 1610 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44345.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1294.5 | |
| All* | Total formula weight | 45639.6 |
