6WE3
Human PARP14 (ARTD8), catalytic fragment in complex with compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protein mono-ADP-ribosyltransferase PARP14 | polymer | 194 | 22172.6 | 2 | UniProt (Q460N5) Pfam (PF00644) In PDB | Homo sapiens (Human) | ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2,Poly [ADP-ribose] polymerase 14,PARP-14 |
| 2 | A, B | 2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}-8-methylquinazolin-4(3H)-one | non-polymer | 304.4 | 2 | Chemie (TZ7) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 8 | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, B: 1611 - 1801 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Ser 1608 | - | expression tag |
| Asn 1609 | - | expression tag |
| Ala 1610 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44345.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2248.5 | |
| All* | Total formula weight | 46593.6 |
