6WDO

Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high Ca2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, A, E, I, O...	Calcium uniporter protein, mitochondrial	polymer	273	32014.9	6	UniProt (Q8NE86) Pfam (PF04678) In PDB	Homo sapiens (Human)	HsMCU,Coiled-coil domain-containing protein 109A
2	H, D, B, F, J...	Essential MCU regulator, mitochondrial	polymer	53	5864.1	8	UniProt (Q9H4I9) Pfam (PF10161) In PDB	Homo sapiens (Human)	Single-pass membrane protein with aspartate-rich tail 1,mitochondrial
3	C, K	Calcium uniporter protein, mitochondrial	polymer	268	31406.2	2	UniProt (Q8NE86) Pfam (PF04678) In PDB	Homo sapiens (Human)	HsMCU,Coiled-coil domain-containing protein 109A
4	Q, S	Calcium uptake protein 1, mitochondrial	polymer	339	39058.5	2	UniProt (Q9BPX6) Pfam (PF13202) In PDB	Homo sapiens (Human)	Atopy-related autoantigen CALC,ara CALC,Calcium-binding atopy-related autoantigen 1
5	R, T	Calcium uptake protein 2, mitochondrial	polymer	310	36682.0	2	UniProt (Q8IYU8) In PDB	Homo sapiens (Human)	EF-hand domain-containing family member A1
6	A, I	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	453295.4
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	453375.6

*Water molecules are not included.