6WDO

Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051560	biological_process	mitochondrial calcium ion homeostasis
B	0036444	biological_process	calcium import into the mitochondrion
B	0051560	biological_process	mitochondrial calcium ion homeostasis
B	1990246	cellular_component	uniplex complex
C	0051560	biological_process	mitochondrial calcium ion homeostasis
D	0036444	biological_process	calcium import into the mitochondrion
D	0051560	biological_process	mitochondrial calcium ion homeostasis
D	1990246	cellular_component	uniplex complex
E	0051560	biological_process	mitochondrial calcium ion homeostasis
F	0036444	biological_process	calcium import into the mitochondrion
F	0051560	biological_process	mitochondrial calcium ion homeostasis
F	1990246	cellular_component	uniplex complex
G	0051560	biological_process	mitochondrial calcium ion homeostasis
H	0036444	biological_process	calcium import into the mitochondrion
H	0051560	biological_process	mitochondrial calcium ion homeostasis
H	1990246	cellular_component	uniplex complex
I	0051560	biological_process	mitochondrial calcium ion homeostasis
J	0036444	biological_process	calcium import into the mitochondrion
J	0051560	biological_process	mitochondrial calcium ion homeostasis
J	1990246	cellular_component	uniplex complex
K	0051560	biological_process	mitochondrial calcium ion homeostasis
L	0036444	biological_process	calcium import into the mitochondrion
L	0051560	biological_process	mitochondrial calcium ion homeostasis
L	1990246	cellular_component	uniplex complex
M	0051560	biological_process	mitochondrial calcium ion homeostasis
N	0036444	biological_process	calcium import into the mitochondrion
N	0051560	biological_process	mitochondrial calcium ion homeostasis
N	1990246	cellular_component	uniplex complex
O	0051560	biological_process	mitochondrial calcium ion homeostasis
P	0036444	biological_process	calcium import into the mitochondrion
P	0051560	biological_process	mitochondrial calcium ion homeostasis
P	1990246	cellular_component	uniplex complex
Q	0005509	molecular_function	calcium ion binding
Q	0006851	biological_process	mitochondrial calcium ion transmembrane transport
R	0005509	molecular_function	calcium ion binding
R	0006851	biological_process	mitochondrial calcium ion transmembrane transport
S	0005509	molecular_function	calcium ion binding
S	0006851	biological_process	mitochondrial calcium ion transmembrane transport
T	0005509	molecular_function	calcium ion binding
T	0006851	biological_process	mitochondrial calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 401

Chain	Residue
A	GLU264
C	GLU264
E	GLU264
G	GLU264

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site_id	AC2
Number of Residues	4
Details	binding site for residue CA I 401

Chain	Residue
I	GLU264
K	GLU264
M	GLU264
O	GLU264

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Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF

Chain	Residue	Details
Q	ASP231-PHE243
Q	ASP421-PHE433

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
R	SER205
Q	GLU432
S	ASP231
S	ASN233
S	ASP235
S	GLU237
S	GLU242
S	ASP421
S	ASP423
S	ASN425
S	GLU427
T	SER205
S	GLU432
Q	ASP235
Q	GLU237
Q	GLU242
Q	ASP421
Q	ASP423
Q	ASN425
Q	GLU427

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site_id	SWS_FT_FI2
Number of Residues	16
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:27099988

Chain	Residue	Details
C	GLU257-PRO265
O	GLU315-LYS332
M	VAL283-LYS305
M	GLU315-LYS332
K	GLU257-PRO265
B	PHE65-ILE84
F	PHE65-ILE84
J	PHE65-ILE84
L	PHE65-ILE84
P	PHE65-ILE84
N	PHE65-ILE84
O	VAL283-LYS305

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000305|PubMed:23051746

Chain	Residue	Details
C	SER92
K	SER92
E	GLY306-LEU314
I	GLY306-LEU314
O	GLY306-LEU314
M	GLY306-LEU314

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q3UMR5

Chain	Residue	Details
C	LYS332
O	ILE141
M	ASP106
M	ILE141
K	LYS332
A	ASP106
A	ILE141
E	ASP106
E	ILE141
I	ASP106
I	ILE141
O	ASP106

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