6WA2
Crystal structure of EGFR(T790M/V948R) in complex with LN3753
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, A, B, C) | Epidermal growth factor receptor | polymer | 328 | 37479.4 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, F, I, K (D, A, B, C) | N-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | non-polymer | 477.5 | 4 | Chemie (TOV) | |||
| 3 | G, H, J (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | L, M, N, O (D, A, B, C) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149917.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2016.4 | |
| All* | Total formula weight | 151933.9 |
