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6WA2

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1D, A, B, CEpidermal growth factor receptorpolymer32837479.44UniProt (P00533)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2D, A, B, CN-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamidenon-polymer477.54Chemie (TOV)
3A, B, CCHLORIDE IONnon-polymer35.53Chemie (CL)
4waterwater18.0235Chemie (HOH)
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Met 790Thr 790engineered mutation
Arg 948Val 948engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight149917.5
Non-Polymers*Number of molecules7
Total formula weight2016.4
All*Total formula weight151933.9
*Water molecules are not included.

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PDB entries from 2024-06-12

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